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Types of Pain in Multiple System Atrophy.

Nicole Campese1,2, Mubasher A Qamar3, Maria Alexandra Chiriac3,4

  • 1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 24, 2026
PubMed
Summary
This summary is machine-generated.

Multiple system atrophy (MSA) is linked to frequent nocturnal, musculoskeletal, and fluctuation-related pain. Understanding these pain types is crucial for developing targeted treatments for MSA patients.

Keywords:
multiple system atrophynon‐motor symptomspainquality of life

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Area of Science:

  • Neurology
  • Pain Medicine
  • Clinical Research

Background:

  • Pain is a prevalent and burdensome symptom in Multiple System Atrophy (MSA), affecting up to 87% of individuals.
  • The specific types and prevalence of pain contributing to the overall burden in MSA remain incompletely understood.

Purpose of the Study:

  • To determine the frequency of various pain types experienced by individuals with Multiple System Atrophy (MSA).
  • To compare pain prevalence in MSA with Parkinson's disease (PD) and healthy controls.

Main Methods:

  • A 2023 web-based survey was administered to individuals with MSA, utilizing the King's Parkinson's Disease Pain Questionnaire (KPPQ) and additional MSA-specific pain questions.
  • Respondents were age, gender, and disease duration-matched with historical cohorts of individuals with PD and healthy controls (n=96 each).

Main Results:

  • Nocturnal pain (73%), musculoskeletal pain (63%), and fluctuation-related pain (62%) were the most common KPPQ-reported pains in MSA.
  • MSA patients reported higher frequencies of most KPPQ pain types compared to healthy controls, with the exception of musculoskeletal pain.
  • Compared to PD patients, MSA individuals experienced less musculoskeletal pain but more orofacial pain.

Conclusions:

  • Multiple System Atrophy (MSA) is associated with diverse pain types, including non-specific and disease-related pains of potentially neuropathic, nociceptive, or nociplastic origin.
  • Identifying distinct pain sources in MSA is essential for developing personalized therapeutic strategies.
  • Targeted treatments addressing both motor and non-motor symptoms are recommended for comprehensive pain management in MSA.