Related Experiment Video
Updated: Jan 25, 2026
09:00
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
Published on: July 7, 2023
4.4K
Types of Pain in Multiple System Atrophy
Nicole Campese1,2, Mubasher A Qamar3, Maria Alexandra Chiriac3,4
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Summary
Multiple system atrophy (MSA) is linked to frequent nocturnal, musculoskeletal, and fluctuation-related pain. Understanding these pain types is crucial for developing targeted treatments for MSA patients.
Area of Science:
- Neurology
- Pain Medicine
- Clinical Research
Background:
- Pain is a prevalent and burdensome symptom in Multiple System Atrophy (MSA), affecting up to 87% of individuals.
- The specific types and prevalence of pain contributing to the overall burden in MSA remain incompletely understood.
Purpose of the Study:
- To determine the frequency of various pain types experienced by individuals with Multiple System Atrophy (MSA).
- To compare pain prevalence in MSA with Parkinson's disease (PD) and healthy controls.
Main Methods:
- A 2023 web-based survey was administered to individuals with MSA, utilizing the King's Parkinson's Disease Pain Questionnaire (KPPQ) and additional MSA-specific pain questions.
- Respondents were age, gender, and disease duration-matched with historical cohorts of individuals with PD and healthy controls (n=96 each).
Main Results:
- Nocturnal pain (73%), musculoskeletal pain (63%), and fluctuation-related pain (62%) were the most common KPPQ-reported pains in MSA.
- MSA patients reported higher frequencies of most KPPQ pain types compared to healthy controls, with the exception of musculoskeletal pain.
- Compared to PD patients, MSA individuals experienced less musculoskeletal pain but more orofacial pain.
Conclusions:
- Multiple System Atrophy (MSA) is associated with diverse pain types, including non-specific and disease-related pains of potentially neuropathic, nociceptive, or nociplastic origin.
- Identifying distinct pain sources in MSA is essential for developing personalized therapeutic strategies.
- Targeted treatments addressing both motor and non-motor symptoms are recommended for comprehensive pain management in MSA.
Related Concept Videos
01:20Pain
1.3K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.3K
01:49Multiple Allele Traits
38.0K
The Concept of Multiple Allelism
38.0K
01:25Multiple Regression
3.8K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.8K
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
02:18Types of Genetic Transfer Between Organisms
30.6K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.6K
01:11Deformation of Member under Multiple Loadings
457
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
457