Related Experiment Video

Updated: Jan 25, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

Association between comorbidities and health-related quality of life in patients with multiple sclerosis

O Mirmosayyeb1, M Barzegar1, M Rezaei2

  • 1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Neurologia
|January 24, 2026
PubMed
Abstract

Insights

Comorbidities significantly impact health-related quality of life (HRQOL) in multiple sclerosis (MS) patients. Physical and psychiatric conditions, unlike autoimmune ones, were linked to reduced HRQOL scores.

Area of Science:

  • Neurology
  • Public Health
  • Psychiatry

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease impacting physical and mental health.
  • Comorbidities are common in people with MS (pwMS) but their effect on health-related quality of life (HRQOL) is not fully understood.

Purpose of the Study:

  • To investigate the association between various comorbidities and HRQOL in pwMS.
  • To determine if physical, psychiatric, or autoimmune comorbidities differentially affect HRQOL.

Main Methods:

  • Cross-sectional study of 976 pwMS in Isfahan, Iran.
  • HRQOL assessed using the 36-Item Short Form Survey (SF-36).
  • Comorbidities extracted from medical records and categorized.

Main Results:

  • Migraine, hypothyroidism, obsessive-compulsive disorder (OCD), and anemia were most common comorbidities.
  • Physical comorbidities (epilepsy, coronary artery disease, eye diseases) and psychiatric conditions (OCD, major depressive disorder) were associated with lower physical component scores (PCS).
  • Psychiatric comorbidities (OCD, major depressive disorder) were linked to lower mental component scores (MCS). Both physical and psychiatric comorbidity groups negatively impacted PCS and MCS.

Conclusions:

  • Comorbidities, particularly physical and psychiatric, are significantly associated with reduced HRQOL in pwMS.
  • Autoimmune comorbidities did not show a significant association with HRQOL in this cohort.
Keywords:
Calidad de vida relacionada con la saludComorbidityComorbilidadEsclerosis múltipleHealth-related quality of lifeMultiple sclerosisPhysical component scorePuntaje del componente físico

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