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Related Concept Videos

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Related Experiment Video

Updated: Jan 25, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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mHealth adherence in pediatric epilepsy: Outcomes of a sequential, multiple assignment, randomized trial (SMART).

Avani C Modi1,2, Janelle L Wagner3, Anup D Patel4

  • 1Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Epilepsia
|January 24, 2026
PubMed
Summary

This study found that mHealth interventions improved medication adherence in pediatric epilepsy caregivers, though benefits didn't last. Seizure freedom improved across all groups, suggesting potential long-term benefits for children with epilepsy.

Keywords:
behavioral interventioncaregiverschildrenseizureself‐management

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Area of Science:

  • Pediatric Neurology
  • Digital Health Interventions
  • Epilepsy Management

Background:

  • Nonadherence to antiseizure medications affects approximately 60% of youth with epilepsy.
  • Underserved populations face significant challenges in medication adherence.
  • mHealth strategies offer a potential solution for improving adherence in pediatric epilepsy.

Purpose of the Study:

  • To evaluate the effectiveness of mHealth intervention strategies for improving medication adherence in caregivers of young children with epilepsy.
  • To compare a treatment group receiving individualized feedback with an active control group.
  • To assess secondary outcomes including longitudinal adherence, seizure freedom, and quality of life.

Main Methods:

  • A multisite, two-stage sequential, multiple assignment, randomized trial (SMART) involving 461 pediatric epilepsy patients.
  • Intervention groups included active control (mHealth education + automated reminders) and treatment (added individualized feedback).
  • Data collected via baseline questionnaires and electronic adherence monitoring over 5 months with follow-ups.

Main Results:

  • The treatment group showed significantly greater adherence improvement (13.2% change) compared to the active control (3.1% change) at stage 1.
  • Adherence rates decreased over time across all intervention strategies.
  • An increased probability of seizure freedom was observed at 6 and 12 months, independent of the specific SMART strategy.

Conclusions:

  • mHealth interventions, including individualized feedback, demonstrated initial efficacy in improving adherence for pediatric epilepsy caregivers.
  • The improvements in adherence did not persist long-term.
  • Seizure freedom improved independently of the intervention strategy, highlighting a potential broader benefit.