Related Experiment Video
Updated: Jan 25, 2026
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
14.9K
Outcomes Following Combined Modality Treatment to the Primary Site in Select Patients With Metastatic Soft Tissue
Andrew J Arifin1, Andrew J Bishop2, Devarati Mitra2
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Division of Radiation Oncology, Verspeeten Family Cancer Centre/Western University, London, Ontario, Canada.
Practical Radiation Oncology
|January 24, 2026
Summary
Combined modality treatment (CMT) using preoperative radiation therapy (RT) and surgery improved local control for metastatic soft tissue sarcoma (STS). This approach offered favorable outcomes and pain reduction with low toxicity in selected patients.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Metastatic soft tissue sarcoma (STS) management can be complex.
- Aggressive treatment of the primary tumor may benefit select patients with metastatic disease.
- Combined modality treatment (CMT) is an option for improving local control.
Purpose of the Study:
- To evaluate the efficacy of CMT using preoperative radiation therapy (RT) followed by surgery for metastatic STS.
- To assess local control, survival, and toxicity in patients receiving CMT.
- To determine the impact of CMT on systemic therapy resumption.
Main Methods:
- Retrospective review of 19 metastatic STS patients treated with CMT (preoperative RT + surgery) between 2018-2023.
- Patients received moderately hypofractionated RT (40.05 Gy in 15 fractions).
- Patient selection criteria included oligometastatic disease and favorable systemic therapy response.
Main Results:
- Two-year local recurrence-free survival was 92%.
- Significant pain reduction (89%) was observed in patients with initial pain.
- Low rates of wound complications (16%) and no grade ≥3 late RT toxicities were reported.
Conclusions:
- CMT with moderately hypofractionated preoperative RT provides favorable local control for selected metastatic STS patients.
- This strategy effectively mitigates pain with low toxicity.
- CMT does not significantly impede the resumption of systemic therapy.
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