Related Experiment Video
Updated: Jan 25, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Molecular background behind lateral elbow pain reduction with Leukocyte-Rich and Leukocyte-Poor Platelet-Rich
Joanna Wałecka1, Paweł Bąkowski2, Marta Jokiel3,4
1Rehasport Clinic, Poznań, Poland. walecka.j@gmail.com.
Purpose:
Degeneration at the common extensor origin leads to lateral elbow pain and reduced quality of life. We conducted a double-blind, randomized, placebo-controlled trial involving 71 patients treated with leukocyte-poor PRP (LP-PRP), leukocyte-rich PRP (LR-PRP), or saline.
Methods:
PRP content was analyzed using flow cytometry, confocal microscopy, and holotomography. Clinical outcomes (Visual Analogue Scale, Oxford Elbow Score) were assessed at baseline and at three, six, 12, 24, and 55 weeks.
Results:
LR-PRP contained 3.8 × more leukocytes and 2.7 × fewer platelets than LP-PRP. Imaging revealed distinct platelet morphology and activation patterns between PRP types. The LP-PRP group showed significantly greater pain reduction at six weeks and improved elbow function from three to six weeks onward.
Conclusion:
LP-PRP produced superior and longer-lasting clinical outcomes compared to LR-PRP and saline.
Clinicaltrials:
GOV: NCT06854666 (retrospectively registered on 2025-01-13).
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