Related Experiment Video
Updated: Jan 26, 2026
11:35
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
58.7K
Cognitive reserve and its contribution to predicting cognitive performance in multiple sclerosis
Sadra Habibi Moini1, Majid Hamidi2, Ali Rezaei2
1Iranian Center of Neurological Research, Neurological Diseases Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis and Related Disorders
|January 24, 2026
Summary
The Cognitive Reserve Index questionnaire (CRIq) better measures cognitive reserve in multiple sclerosis (MS) patients than education alone. CRIq significantly correlates with cognitive function and improves predictive models for cognitive decline in MS.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Clinical Neurology
Background:
- Cognitive impairment is common in multiple sclerosis (MS).
- Cognitive reserve (CR) may protect against cognitive decline.
- This study investigates CR, cognitive scores, and patient characteristics in MS.
Purpose of the Study:
- To explore the association between CR (measured by CRIq), cognitive scores, and patient characteristics in MS.
- To compare the predictive value of CRIq versus education alone for cognitive function in MS.
Main Methods:
- 81 MS patients (39.22 ± 8.09 years, 64% female) were assessed.
- Cognitive function was evaluated using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).
- Cognitive Reserve Index questionnaire (CRIq) and depression questionnaires were administered.
Main Results:
- CRIq scores significantly correlated with information processing speed, verbal memory, and visuospatial memory (p < 0.001).
- CRIq improved cognitive function models, explaining an additional 10.8%–18.7% of variance beyond age and clinical predictors.
- Education did not significantly predict cognitive function beyond CRIq scores.
Conclusions:
- The CRIq offers a more comprehensive measure of cognitive reserve than education alone in adults.
- This highlights the multidimensional nature of cognitive enrichment and its importance in managing cognitive health.
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