Related Experiment Video

Updated: Jan 26, 2026

Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study
09:36

Standardization of Basket Use in Sialendoscopy: A Ten-Year Retrospective Study

Published on: June 6, 2025

550

Real-world daptomycin use with a focus on muscle toxicity: A multicentric retrospective study

C Airaud1, E Demay2, V Dias Meireles3

  • 1University Hospital (CHU), Poitiers, France.

International Journal of Antimicrobial Agents
|January 24, 2026
PubMed
Abstract

Insights

Daptomycin use for Gram-positive infections shows inconsistent safety monitoring, increasing muscle toxicity risk. Co-prescribing statins, fibrates, or obesity independently elevate this risk, necessitating careful medication review and CK testing.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Infectious Diseases

Background:

  • Daptomycin is a key antibiotic for Gram-positive infections.
  • Muscle toxicity is a known adverse effect of daptomycin therapy.
  • Real-world adherence to daptomycin safety monitoring guidelines is not well-documented.

Purpose of the Study:

  • To assess daptomycin prescribing patterns in French university hospitals.
  • To identify factors associated with daptomycin-induced muscle toxicity.
  • To evaluate the consistency of safety monitoring practices.

Main Methods:

  • Retrospective multicenter study of 1,407 adult patients treated with daptomycin.
  • Data collected on demographics, treatment, monitoring, and adverse events.
  • Muscle toxicity defined by creatine kinase (CK) elevation or rhabdomyolysis; logistic regression used for risk factor analysis.

Main Results:

  • High-dose daptomycin (≥8 mg/kg/day) was used in 93.9% of patients.
  • CK monitoring occurred in only 34.2% of patients.
  • Muscle toxicity reported in 4.9%, including rhabdomyolysis in 2.7%.
  • Concomitant use of statins/fibrates (OR 6.68) and obesity (OR 2.25) were significant risk factors for muscle toxicity.

Conclusions:

  • Daptomycin safety monitoring, particularly CK testing, was inconsistent despite high-dose usage.
  • Systematic CK monitoring and careful evaluation of myotoxic co-medications are crucial.
  • Mitigating daptomycin-related muscle toxicity requires vigilant clinical practice.
Keywords:
Adverse eventsDaptomycinHealthcare-associated infectionsSafety

More Related Videos

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K
Real-Time fMRI Brain Mapping in Animals04:05

Real-Time fMRI Brain Mapping in Animals

Published on: September 24, 2020

4.0K

Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.8K
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
5.6K
Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
For example, consider a student who struggles to understand their...
456
Coping Strategies: Emotion Focused01:20

Coping Strategies: Emotion Focused

Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
459
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.4K
Methods of Documentation IV: Focus Charting01:26

Methods of Documentation IV: Focus Charting

Focus Charting, also known as the focus charting system or "focus documentation," is a systematic documentation approach used in healthcare to organize patient information in medical records.
It typically involves three columns for recording information:
1.7K