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Related Concept Videos

Schizophrenia01:17

Schizophrenia

847
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Histone Variants at the Centromere02:30

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
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Related Experiment Video

Updated: Jan 26, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE.

Yixing Liu1,2, Junyang Wang3, Hong Yang4

  • 1Department of Psychosomatics and Psychiatry, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, School of Medicine, Advanced Institute for Life and Health, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.

Nature Communications
|January 24, 2026
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Summary
This summary is machine-generated.

Two genetic variants at the 1p36.23 locus increase schizophrenia risk by upregulating the RERE gene. This gene impacts neurodevelopment and synaptic function, contributing to the disorder.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Genome-wide association studies (GWAS) implicate the 1p36.23 chromosomal region in schizophrenia susceptibility.
  • The specific genetic variants and underlying biological mechanisms driving this association remain unclear.

Purpose of the Study:

  • To identify functional genetic variants at the 1p36.23 schizophrenia risk locus.
  • To elucidate the molecular mechanisms by which these variants contribute to schizophrenia pathogenesis.

Main Methods:

  • Identification and characterization of functional variants (rs159961, rs301792) within the RERE gene introns.
  • Assessment of allele-specific enhancer activity and transcription factor binding (REST, POLR2A).
  • Analysis of RERE expression levels in human brain tissue and its functional impact on neurogenesis, dendritic morphology, and synaptic transmission in vitro.

Main Results:

  • Two variants, rs159961 and rs301792, demonstrate allele-specific enhancer activity, increasing RERE expression by altering transcription factor binding.
  • Elevated RERE levels were observed in the brains of schizophrenia patients.
  • RERE overexpression negatively impacted neurogenesis, dendritic complexity, and excitatory synaptic function, partly through regulation of the Grin2a gene.

Conclusions:

  • Functional variants rs159961 and rs301792 confer schizophrenia risk by increasing RERE expression.
  • Upregulated RERE disrupts neuronal development and synaptic function, providing a mechanistic link to schizophrenia.
  • This study highlights RERE as a key gene in schizophrenia etiology, influenced by common genetic variants.