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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
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Copper-Chelated Thermosensitive Hybrid Hydrogels for Peri-Implantitis Treatment.
Xinxin Ding1, Xue Jiang1, Yi Zhang1
1Department of Oral Implantology, Shanghai Ninth People's Hospital, School of Medicine, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Advanced Healthcare Materials
|January 25, 2026
Summary
This study developed a novel thermosensitive hybrid hydrogel for peri-implantitis treatment. The copper-enhanced hydrogel effectively kills bacteria and promotes bone repair, offering a promising solution for patients.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Implantology
Background:
- Peri-implantitis (PI) is a prevalent condition causing bone loss around dental implants, significantly impacting patient quality of life.
- Existing thermosensitive chitosan-based hydrogels for PI treatment have limitations in mechanical strength, hindering bone repair efficacy.
- Copper ions exhibit concentration-dependent antibacterial properties beneficial for combating PI-associated infections.
Purpose of the Study:
- To fabricate a copper-chelated thermosensitive hybrid hydrogel (Cu/CGT) with enhanced mechanical properties for peri-implantitis treatment.
- To evaluate the in vitro and in vivo physical, biocompatibility, and antibacterial properties of the developed Cu/CGT hydrogel.
- To assess the potential of Cu/CGT hydrogel in promoting osteogenic differentiation and suppressing inflammation for improved bone regeneration.
Main Methods:
- Fabrication of a hybrid hydrogel by incorporating tetraethoxysilane into a copper-doped chitosan and β-glycerophosphate solution.
- Comprehensive material characterization, including assessment of compressive modulus.
- In vitro and in vivo biocompatibility, antibacterial efficacy against pathogenic bacteria, and osteogenic differentiation assays were performed.
Main Results:
- The 1Cu/CGT hydrogel demonstrated improved compressive modulus compared to conventional hydrogels.
- The hydrogel exhibited significant antibacterial activity against pathogenic bacteria and suppressed inflammation.
- Enhanced osteogenic differentiation was observed, indicating improved bone-repairing potential.
- An ideal copper ion release profile was achieved, contributing to the hydrogel's overall biomedical performance.
Conclusions:
- A novel thermosensitive hybrid hydrogel (Cu/CGT) was successfully developed for peri-implantitis treatment.
- The Cu/CGT hydrogel possesses excellent antibacterial properties and promotes osteogenic differentiation and bone repair.
- This innovative hydrogel shows significant potential for clinical application in treating peri-implantitis.
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