Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...

Hydrogen Bonds

Hydrogen Bonds

Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....

Atomic Orbitals

Atomic Orbitals

An atomic orbital represents the three-dimensional regions in an atom where an electron has the highest probability to reside. The radial distribution function indicates the total probability of finding an electron within the thin shell at a distance r from the nucleus. The atomic orbitals have distinct shapes which are determined by l, the angular momentum quantum number. The orbitals are often drawn with a boundary surface, enclosing densest regions of the cloud.

Hybridization of Atomic Orbitals I

Hybridization of Atomic Orbitals I

The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...

The Atomic Theory of Matter

The Atomic Theory of Matter

The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...

Hybridization of Atomic Orbitals II

Hybridization of Atomic Orbitals II

sp3d and sp3d 2 Hybridization

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Potassium thiocyanate-promoted four-component alkoxysulfenylation of styrenes with imidazo[1,2-<i>a</i>]pyridines and alcohols.

RSC advances·2026

Same author

Synthetic ecology of coastal ecosystems.

Cell reports·2026

Same author

Photoperiod-dependent protein and lipid biosynthesis in Auxenochlorella pyrenoidosa cultivated using food waste hydrolysate.

Journal of environmental management·2026

Same author

Docetaxel Oral Delivery System Using Natural Nanoparticles Derived from Ganoderma: Enhanced Pharmacokinetics, Potent Cytotoxicity, and Macrophage-Activating Properties.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

A speech prediction model based on codec modeling and transformer decoding.

Computer speech & language·2026

Same author

Spontaneous pregnancy in a woman with diminished ovarian reserve following dietary supplementation with major royal jelly proteins: A case report.

Medicine·2026

Search research articles

Related Experiment Video

Updated: Jan 26, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

Where Enantioselection is Set: A Mechanistic Framework for Asymmetric Hydrogen-Atom Transfer.

Zhongyun Xu¹, Yufeng Yang¹, Yong-Qiang Zhang¹

¹School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.

Angewandte Chemie (International Ed. in English)

|January 25, 2026

Summary

Asymmetric hydrogen-atom transfer (HAT) is challenging but achievable. New catalytic strategies precisely control stereochemistry during the H-transfer step, enabling high enantioselectivity in radical chemistry.

Keywords:

Asymmetric catalysis Enantiocontrol Hydrogen‐atom transfer Radical chemistry

More Related Videos

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Published on: June 28, 2017

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

Published on: December 1, 2020

Related Experiment Videos

Last Updated: Jan 26, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

Published on: June 28, 2017

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures

Published on: December 1, 2020

Area of Science:

Organic Chemistry
Catalysis
Stereochemistry

Background:

Hydrogen-atom transfer (HAT) is fundamental to radical chemistry.
Achieving high enantioselectivity in asymmetric HAT is difficult due to radical reactivity and early transition states.
Recent advancements have enabled stereocontrol at the crucial H-transfer step.

Purpose of the Study:

To organize and review recent advances in asymmetric hydrogen-atom transfer (HAT).
To present a mechanistic framework for understanding enantioselection in HAT.
To highlight opportunities for future development in asymmetric radical chemistry.

Main Methods:

Categorization of asymmetric HAT into five distinct regimes based on stereochemical control.
Analysis of representative catalytic systems (small-molecule, metalloradical, cooperative, peptide, enzymatic).
Illustration of how catalysts achieve enantioselection through geometric control, guided delivery, selective abstraction, or confined environments.

Main Results:

Asymmetric HAT can be achieved with high enantioselectivity through precise catalyst engineering.
Five distinct regimes of asymmetric HAT are identified, each with specific stereochemical logics.
Catalysts control enantioselection by influencing radical geometry, H-delivery, abstraction, or donor-acceptor pairing.

Conclusions:

A unified mechanistic framework spans synthetic and biocatalytic asymmetric HAT.
Understanding the distinct stereochemical logics in each regime is crucial.
Precisely orchestrated H-atom transfer offers significant opportunities for advancing asymmetric radical chemistry.