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Renal function impairment in children with intestinal failure receiving parenteral nutrition: A descriptive cohort

Amanda M Braga da Mata1, Heitor Pons Leite1,2, Eduardo F Hatanaka1,2

  • 1Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.

JPEN. Journal of Parenteral and Enteral Nutrition
|January 25, 2026
PubMed

Insights

Children with intestinal failure frequently experience kidney dysfunction, including impaired glomerular filtration rate and tubular issues like hypercalciuria and phosphaturia. This study identifies key risk factors for renal problems in these vulnerable patients.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Intestinal Rehabilitation

Background:

  • Children with intestinal failure (IF) face significant risks of kidney dysfunction.
  • Contributing factors to renal impairment in IF are not fully understood.
  • This study investigates risk factors for glomerular and tubular renal dysfunction in pediatric IF.

Purpose of the Study:

  • To identify risk factors for glomerular dysfunction in children with IF.
  • To identify risk factors for tubular dysfunction in children with IF.
  • To characterize renal function in children receiving parenteral nutrition for IF.

Main Methods:

  • Retrospective cohort study of 25 children with IF on parenteral nutrition.
  • Glomerular function assessed by estimated glomerular filtration rate (eGFR) and urinary microalbumin/creatinine ratio.
  • Tubular function assessed by urinary calcium/creatinine ratio and tubular reabsorption of phosphate/eGFR.

Main Results:

  • Two patients had decreased eGFR; four showed microalbuminuria at time point 1.
  • Hypercalciuria was present in 10/23 and 9/24 children; 5 maintained it.
  • Reduced tubular phosphate reabsorption/eGFR occurred in 6/12 and 2/14 children.

Conclusions:

  • Two-thirds of children with IF exhibited renal dysfunction.
  • Observed dysfunctions included microalbuminuria, reduced eGFR, hypercalciuria, and phosphaturia.
  • Further research is needed to elucidate specific risk factors.
Abstract

Keywords:
childintestinal failurekidney diseaseskidney tubules/abnormalitiespediatrics

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