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Related Concept Videos

Classification of Illness01:17

Classification of Illness

8.6K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.6K
Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Factors Affecting Illness01:18

Factors Affecting Illness

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When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.2K
Concepts of Health and Illness01:29

Concepts of Health and Illness

17.6K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
17.6K
Dimensions of Health and Illness01:21

Dimensions of Health and Illness

10.8K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
10.8K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.3K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
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Related Experiment Video

Updated: Jan 26, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

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Abnormalities of liver function during critical illness.

Philippe Meersseman1, Alexander Wilmer1, Lies Langouche2

  • 1Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital Leuven.

Current Opinion in Critical Care
|January 25, 2026
PubMed
Summary
This summary is machine-generated.

Liver dysfunction affects up to 40% of ICU patients, increasing mortality. Early detection via dynamic liver function tests and understanding acute-on-chronic liver failure (ACLF) are crucial for better outcomes.

Keywords:
ICUacute liver failureacute-on-chronic liver failureliver failuresepsis

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Related Experiment Videos

Last Updated: Jan 26, 2026

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

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Area of Science:

  • Critical care medicine
  • Hepatology
  • Internal medicine

Background:

  • Liver dysfunction is common in critically ill patients (20-40%) and linked to worse outcomes.
  • Abnormal liver function tests (LFTs) can stem from sepsis, drug toxicity, hypoxia, or pre-existing liver disease.
  • Hepatic dysfunction can be a primary reason for ICU admission or develop during hospitalization.

Purpose of the Study:

  • To review recent advancements in understanding liver dysfunction in critically ill patients.
  • To emphasize the diagnosis and management of acute-on-chronic liver failure (ACLF).
  • To highlight the importance of dynamic liver function testing for early detection and prognostication.

Main Methods:

  • Review of recent literature on liver dysfunction in critical illness.
  • Focus on dynamic liver function tests (e.g., indocyanine green clearance).
  • Exploration of evolving concepts in acute-on-chronic liver failure (ACLF).

Main Results:

  • Dynamic liver function testing aids in early detection and prognostication.
  • ACLF is recognized as a systemic condition requiring timely intervention.
  • Understanding the link between hepatic dysfunction and multiorgan failure is key.

Conclusions:

  • Recent advances improve understanding of liver dysfunction mechanisms, diagnosis, and management.
  • Particular emphasis is placed on acute-on-chronic liver failure (ACLF).
  • Improved management strategies are essential for this patient population.