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Updated: Jan 27, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
Published on: September 23, 2021
Associations of intrinsic capacity decline with frailty and disability in old inpatients: a retrospective study
Xiuping Wu1, Suna Fu1, Jianhong Yu1
1Geriatric Medicine Department, The affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, China.
Objectives:
There are increasing number of hospital admissions for old adults. The significance of frailty and disability has been recognized for this population. Hence, this paper investigates the relationship of intrinsic capacity (IC) decline with frailty and disability among hospitalized old patients.
Methods:
A comprehensive review was conducted for hospitalization records of old patients aged ≥60 years at the Affiliated Hospital of Shaoxing University of Arts and Sciences from January 2022 to December 2022. To delve deeper into the interplay of intrinsic capacity (IC) with frailty and disability, we employed robust statistical methodologies, including the Spearman correlation coefficient analysis and a multivariate logistic regression model.
Results:
914 patients were included, with 209 (22.9%) experiencing frailty, 166 (18.2%) experiencing disability, and 607 (66.4%) demonstrating IC decline across various dimensions. Multivariate logistic regression analysis revealed that IC decline was an independent risk factor for frailty (OR = 6.41, 95% CI: 3.61-11.39) and disability (OR = 5.11, 95% CI: 2.79-9.34) among old patients.
Conclusion:
IC decline is prevalent among hospitalized old individuals and is correlated with frailty and disability. Preventing IC decline is conducive to reducing the incidence of frailty and disability.
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