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Structural network topology and cognitive control in very preterm born young adults.
Merle J Marek1, Dieter Wolke2, Christian Sorg3
1Psychological Methods and Statistics, Department of Psychology, Carl von Ossietzky Universität Oldenburg, Germany.
Neuroimage. Clinical
|January 25, 2026
View abstract on PubMed
Summary
Individuals born very preterm (<32 weeks gestation) show lasting deficits in cognitive control and reduced brain network integration into adulthood. These findings highlight the need for continued support for very preterm individuals.
Area of Science:
- Neuroscience
- Developmental Psychology
- Medical Imaging
Background:
- Very preterm (VPT) birth (<32 weeks gestation) poses risks for long-term neurodevelopmental outcomes.
- Cognitive control and brain network topology are crucial for adaptive functioning.
- Longitudinal studies are essential to understand the lasting impacts of VPT birth.
Purpose of the Study:
- To investigate the long-term effects of VPT birth on cognitive control and structural brain network topology at 26 years of age.
- To examine brain-behavior associations between cognitive control and brain network characteristics in VPT and full-term (FT) individuals.
- To identify potential targets for intervention to mitigate neurodevelopmental impacts of preterm birth.
Main Methods:
- Utilized data from the Bavarian Longitudinal Study (BLS) including 61 VPT and 79 FT individuals.
Main Results:
- Full-term individuals scored significantly higher in cognitive control speed compared to the very preterm group (0.742 SD difference, p=0.001).
- The very preterm group exhibited reduced structural network integration, evidenced by lower global efficiency and average degree.
- No significant group differences were found in network segregation (clustering coefficient).
Conclusions:
- Very preterm birth is associated with persistent cognitive control deficits and impaired structural brain network integration in adulthood.
- Structural brain network characteristics were not significantly linked to cognitive control abilities in this cohort.
- Findings emphasize the necessity of ongoing support and interventions for individuals born very preterm to address lasting neurodevelopmental consequences.


