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  1. Home
  2. Structural Network Topology And Cognitive Control In Very Preterm Born Young Adults.
  1. Home
  2. Structural Network Topology And Cognitive Control In Very Preterm Born Young Adults.

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Structural network topology and cognitive control in very preterm born young adults.

Merle J Marek1, Dieter Wolke2, Christian Sorg3

  • 1Psychological Methods and Statistics, Department of Psychology, Carl von Ossietzky Universität Oldenburg, Germany.

Neuroimage. Clinical
|January 25, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Individuals born very preterm (<32 weeks gestation) show lasting deficits in cognitive control and reduced brain network integration into adulthood. These findings highlight the need for continued support for very preterm individuals.

Keywords:
Cognitive controlGraph theoryIntegration and segregationStructural connectomeStructural equation modellingVery preterm birth

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Medical Imaging

Background:

  • Very preterm (VPT) birth (<32 weeks gestation) poses risks for long-term neurodevelopmental outcomes.
  • Cognitive control and brain network topology are crucial for adaptive functioning.
  • Longitudinal studies are essential to understand the lasting impacts of VPT birth.

Purpose of the Study:

  • To investigate the long-term effects of VPT birth on cognitive control and structural brain network topology at 26 years of age.
  • To examine brain-behavior associations between cognitive control and brain network characteristics in VPT and full-term (FT) individuals.
  • To identify potential targets for intervention to mitigate neurodevelopmental impacts of preterm birth.

Main Methods:

  • Utilized data from the Bavarian Longitudinal Study (BLS) including 61 VPT and 79 FT individuals.
  • Assessed cognitive control using multi-group confirmatory factor analysis.
  • Analyzed structural brain network topology via diffusion-weighted MRI, tractography, and graph-theoretic analysis.
  • Main Results:

    • Full-term individuals scored significantly higher in cognitive control speed compared to the very preterm group (0.742 SD difference, p=0.001).
    • The very preterm group exhibited reduced structural network integration, evidenced by lower global efficiency and average degree.
    • No significant group differences were found in network segregation (clustering coefficient).

    Conclusions:

    • Very preterm birth is associated with persistent cognitive control deficits and impaired structural brain network integration in adulthood.
    • Structural brain network characteristics were not significantly linked to cognitive control abilities in this cohort.
    • Findings emphasize the necessity of ongoing support and interventions for individuals born very preterm to address lasting neurodevelopmental consequences.