Related Experiment Video

Updated: Jan 27, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

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6-Mercaptopurine vs Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study

Ludwig Jesse Horst1, Alexander Fierenz2, Bernardo Canhão3

  • 1I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|January 25, 2026
PubMed
Summary

For autoimmune hepatitis (AIH) patients intolerant to azathioprine (AZA), both 6-mercaptopurine (6-MP) and mycophenolate mofetil (MMF) maintained biochemical response. MMF showed better tolerability, but 6-MP is a viable option, especially for women of reproductive age.

Keywords:
AIHAzathioprine intoleranceImmunosuppressionSecond-line Therapy

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