Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

2.8K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.8K
Coronary Circulation01:21

Coronary Circulation

7.0K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.0K
Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

2.9K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
2.9K
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

10.5K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
10.5K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

840
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
840
Retroviruses02:33

Retroviruses

14.8K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
14.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The silent pharmacist: Harnessing the gut microbiome to improve therapy in hematologic malignancies.

Translational oncology·2026
Same author

Therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles combined with injectable hydrogels in bone defect repair: a systematic review and meta-analysis of preclinical studies.

Journal of biological engineering·2026
Same author

Frequency of prognostically important acute myeloid leukemia mutations in the Iranian population: A systematic review and meta-analysis.

Caspian journal of internal medicine·2026
Same author

Different SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD).

Health science reports·2026
Same author

The microbial metabolome: remodeling the therapeutic landscape in hematologic malignancies.

NPJ biofilms and microbiomes·2026
Same author

TIM-3 in AML: pathogenic roles and therapeutic targetability.

Clinical and experimental medicine·2026

Related Experiment Video

Updated: Jan 27, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

597

Circulating biomarkers in leukemia.

Aiyun Dong1, Mehdi Jahedi Zargar2, Amirhossein Mirzazadeh3

  • 1Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030001, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 25, 2026
PubMed
Summary

Liquid biopsies offer a less invasive way to monitor blood cancers using circulating biomarkers like cell-free DNA (cfDNA). These blood tests help track treatment effectiveness and detect relapse earlier than traditional methods.

Keywords:
Circulating biomarkersLeukemiaLiquid biopsyMinimal residual disease (MRD)Precision hematology

More Related Videos

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

11.0K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

597
Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

11.0K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.7K

Area of Science:

  • Hematology
  • Oncology
  • Molecular Diagnostics

Background:

  • Liquid biopsy analyzes circulating biomarkers (cfDNA, ctDNA, miRNAs, EVs) for real-time insights into hematologic malignancies.
  • Blood-based assays offer serial sampling advantages over bone-marrow biopsy for capturing temporal changes and heterogeneity.

Purpose of the Study:

  • To review current technologies, clinical applications, and translational opportunities for circulating biomarkers in leukemia.
  • To discuss challenges hindering the clinical implementation of these biomarkers.

Main Methods:

  • Review of current high-throughput sequencing and digital PCR technologies for biomarker detection.
  • Analysis of clinical studies correlating circulating tumor DNA (ctDNA) kinetics with patient outcomes.
  • Evaluation of barriers to assay standardization and interpretation of low-frequency variants.

Main Results:

  • Advances in technology improve sensitivity for detecting minimal residual disease (MRD), clonal evolution, and resistance mutations.
  • ctDNA kinetics correlate with progression-free and overall survival in lymphoid and myeloid malignancies, suggesting its potential as an early surrogate of treatment benefit.
  • Sensitivity varies by disease biology, necessitating combination with marrow-based MRD and leukocyte sequencing pending standardization.

Conclusions:

  • Circulating biomarkers hold promise for personalized treatment decisions and early relapse detection in hematologic malignancies.
  • Standardization of assays, understanding biological variability, and robust interpretation frameworks are crucial for clinical integration.
  • Further prospective standardization is needed before widespread adoption, especially for ctDNA, in combination with traditional methods.