Related Experiment Video
Updated: Jan 27, 2026
Author Spotlight: A Personalized Approach Towards Investigating Alzheimer's Disease Using an In Vitro Blood-Brain Barrier Model
Published on: October 20, 2023
Mechanisms and therapeutic potential of migrasomes in neurological disorders
Simeng Zhang1, Yanhua Yang1, Tiancheng Zhang1
1School of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China.
Abstract:
Migrasomes, a recently identified class of organelles, form at the tips or intersections of retraction fibers during cell migration. These structures carry various bioactive cargoes, including proteins, mRNAs, and cytokines, and play significant roles in intercellular communication, immune regulation, and tissue homeostasis. As specialized membrane structures generated during cell migration, migrasomes are not only involved in physiological processes such as embryonic development and vascular homeostasis but are also critically implicated in the pathogenesis of neurological disorders. In this review, we outline the fundamental biological characteristics and functions of migrasomes, provide an in-depth analysis of their pathological mechanisms in neurological diseases, and evaluate their clinical potential as novel diagnostic biomarkers, drug delivery vehicles, and therapeutic targets. Overall, this review offers new perspectives for precision diagnostics and therapeutics of neurological diseases and lays a foundation for diagnosing and treating migrasome-related pathologies.
Insights
Migrasomes are novel organelles involved in cell communication and tissue health. This review explores their role in neurological diseases, highlighting potential for diagnostics and therapeutics.
Area of Science:
- Cell Biology
- Neuroscience
- Immunology
Background:
- Migrasomes are newly discovered organelles formed during cell migration.
- They transport bioactive molecules, influencing intercellular communication and tissue homeostasis.
- Migrasomes are implicated in both physiological processes and neurological disease pathogenesis.
Purpose of the Study:
- To review the fundamental characteristics and functions of migrasomes.
- To analyze the pathological mechanisms of migrasomes in neurological diseases.
- To evaluate the clinical potential of migrasomes in diagnostics and therapeutics.
Main Methods:
- Literature review of migrasome biology and function.
- Analysis of migrasome involvement in neurological disorder pathology.
- Evaluation of clinical applications for migrasomes.
Main Results:
- Migrasomes are key players in cell migration and intercellular signaling.
- Their dysfunction is linked to the pathogenesis of neurological disorders.
- Migrasomes show promise as biomarkers and therapeutic targets.
Conclusions:
- Migrasomes represent a significant area for understanding neurological diseases.
- They offer novel avenues for precision diagnostics and targeted therapies.
- Further research can establish a foundation for treating migrasome-related pathologies.
More Related Videos
06:12Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
Published on: March 13, 2018
08:17A Semantic Priming Event-related Potential ERP Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder
Published on: April 12, 2018
Related Concept Videos
02:18Intrinsically Disordered Proteins
01:13Therapeutic Index
00:52Potential Energy
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
01:30Other Disorders of Digestive System
01:27Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...