Related Experiment Video

Updated: Jan 27, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.5K

Prognostic utility of circulating tumor DNA in classical hodgkin lymphoma: A systematic review and individual

Amirhossein Shahsavand1, Shayan Forghani1, Mohammadamin Kharaghani1

  • 1Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.

Critical Reviews in Oncology/Hematology
|January 25, 2026
PubMed

Insights

Circulating tumor DNA (ctDNA) levels can predict disease progression and mortality in Hodgkin lymphoma (HL) patients. Higher ctDNA concentrations, especially after treatment, indicate a worse prognosis and increased risk of death.

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Biomarkers

Background:

  • Over 20% of Hodgkin lymphoma (HL) patients experience treatment failure.
  • Identifying prognostic markers is crucial for optimizing HL management.
  • Circulating tumor DNA (ctDNA) is an emerging biomarker in various cancers.

Purpose of the Study:

  • To evaluate the prognostic utility of ctDNA in predicting outcomes for HL patients.
  • To assess the association between ctDNA levels and progression-free survival (PFS) and overall survival (OS).
  • To determine how ctDNA's prognostic value changes over the course of treatment.

Main Methods:

  • Systematic literature search of major databases (PubMed, Embase, etc.) up to March 2025.
  • Extraction and digitization of survival data from Kaplan-Meier curves.
  • Application of a hierarchical Bayesian model to estimate hazard ratios (HRs) and restricted mean survival times (RMSTs).

Main Results:

  • Analysis of 10 studies with 1,158 HL patients.
  • Elevated baseline ctDNA associated with inferior PFS (HR: 2.74) and OS (HR: 2.49).
  • Interim and end-of-treatment ctDNA positivity significantly predicted worse PFS and OS, with increasing prognostic strength over time.

Conclusions:

  • Higher ctDNA concentration in HL patients correlates with increased disease progression and mortality.
  • The prognostic significance of ctDNA intensifies as treatment progresses.
  • Clinical utility requires assay standardization, threshold validation, and longitudinal assessment.

Keywords:
Bayesian meta-analysisCtDNAHodgkin lymphomaLiquid biopsyMRDNGS

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