Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

5.0K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.0K
Pigmentation01:19

Pigmentation

4.1K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.1K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

16.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
16.2K
Activation Energy01:26

Activation Energy

86.5K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.5K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

38.5K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
38.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kukui nut oil (Aleurites moluccanus seed oil) promotes hair growth by activating the Nrf2/ARE-AKR1C family-PGF2α signaling axis.

Scientific reports·2026
Same author

[Comprehensive characterization of primary ciliated cells in inflammatory skin diseases].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica·2026
Same author

Involvement of interaction between TRPM2 and IKCA1 in temperature-dependent movement and IL-1β production in mouse microglia.

The journal of physiological sciences : JPS·2026
Same author

Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in <i>Drosophila</i>.

iScience·2026
Same author

Genetic inactivation of TRPM4 does not alter the temperature-dependent movement of mouse microglia.

The journal of physiological sciences : JPS·2026
Same author

Hibernation-inspired musculoskeletal resilience: comparative mechanisms of adaptation to disuse and unloading.

Biological reviews of the Cambridge Philosophical Society·2026

Related Experiment Video

Updated: Jan 27, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.6K

MA-T Activates Human TRPV4 in the Non-pigmented Ciliary Epithelial Cells.

Qianwen Luo1, Manami Toriyama1, Miho Hashimoto1,2

  • 1Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University (Currently known as The University of Osaka), 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Biological & Pharmaceutical Bulletin
|January 25, 2026
PubMed
Summary
This summary is machine-generated.

Matching transformation system (MA-T) activates human transient receptor potential cation channel V4 (hTRPV4), a redox sensor. This suggests MA-T may be a potential therapeutic agent for diseases linked to hTRPV4.

Keywords:
ciliary epithelial cellmatching transformation systemperchloritetransient receptor potential vanilloid 4 (TRPV4)

More Related Videos

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.4K
Author Spotlight: Development of an Efficient and Feasible Method of Retinal Pigment Epithelial Cell Freezing
07:03

Author Spotlight: Development of an Efficient and Feasible Method of Retinal Pigment Epithelial Cell Freezing

Published on: November 3, 2023

1.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.6K
Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.4K
Author Spotlight: Development of an Efficient and Feasible Method of Retinal Pigment Epithelial Cell Freezing
07:03

Author Spotlight: Development of an Efficient and Feasible Method of Retinal Pigment Epithelial Cell Freezing

Published on: November 3, 2023

1.1K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • The Matching Transformation system (MA-T) produces aqueous chlorine dioxide on demand.
  • MA-T has applications in antibacterial and cancer therapies.
  • Human transient receptor potential cation channel subfamily V member 4 (hTRPV4) acts as a redox sensor.

Purpose of the Study:

  • To investigate the effect of MA-T on hTRPV4.
  • To determine if MA-T can activate hTRPV4.
  • To explore the potential of MA-T in treating TRPV4-related diseases.

Main Methods:

  • Calcium (Ca2+) imaging experiments.
  • Patch-clamp electrophysiology.
  • HEK293T cell line and human non-pigmented ciliary epithelial cells.

Main Results:

  • 10 ppm MA-T was found to activate hTRPV4 in HEK293T cells.
  • MA-T induced an increase in cytosolic calcium concentration via hTRPV4 activation in human non-pigmented ciliary epithelial cells.

Conclusions:

  • MA-T activates hTRPV4.
  • MA-T's ability to modulate hTRPV4 suggests its potential therapeutic utility.
  • Further research into MA-T for TRPV4-related diseases is warranted.