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Polygonati Rhizoma: Geographic Distribution, Traditional Use, Component Transformation, Pharmacological Activity, and
Hong Guo1, Rui Yao1, Xiaohan Guo1
1National Institutes for Food and Drug Control, Beijing 102629, China.
The American Journal of Chinese Medicine
|January 25, 2026
Summary
Polygonati Rhizoma (PR), a traditional herb, offers health benefits like anti-aging and neuroprotection due to its rich bioactive compounds. Processing PR enhances its antioxidant capacity and reduces irritation, but further research is needed on its mechanisms and quality control.
Area of Science:
- Ethnobotany and Pharmacology
- Traditional Chinese Medicine
- Natural Product Chemistry
Background:
- Polygonati Rhizoma (PR) is a dual-use herb with a long history in traditional medicine.
- Modern analysis reveals PR is rich in polysaccharides, saponins, flavonoids, and polyphenols.
- Traditional uses include nourishing liver/kidneys and prolonging lifespan.
Purpose of the Study:
- To review the geographic distribution, applications, and pharmacological activities of PR.
- To examine the transformation of bioactive constituents during PR processing.
- To identify research gaps in understanding PR's functional components and quality control.
Main Methods:
- Systematic literature review of traditional and modern studies on Polygonati Rhizoma.
- Analysis of bioactive constituents and their changes during processing.
- Critical evaluation of existing research on pharmacological activities and mechanisms.
Main Results:
- PR contains bioactive compounds like polysaccharides, saponins, flavonoids, and polyphenols with anti-aging, antidepressant, anti-osteoporotic, and neuroprotective effects.
- Processing PR mitigates irritation from calcium oxalate raphides and enhances antioxidant/anti-aging properties.
- Mechanistic studies on flavonoids, polyphenols, and oligosaccharides are underexplored.
Conclusions:
- Further research is needed on the mechanisms of PR's functional components, especially flavonoids and polyphenols.
- Establishing correlations between processing, composition, efficacy, and quality control is crucial for scientific validation.
- This review aims to advance PR exploration, promote sustainable use, and develop evidence-based quality standards.
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