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Updated: Jan 27, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Clonal determinants of organotropism and survival in metastatic uveal melanoma
Bailey S C L Jones1, Emma Hammes2, Patrick C Demkowicz3
1Department of Ophthalmology & Visual Science, Yale School of Medicine, New Haven, CT, USA.
Abstract:
Uveal melanoma (UM), the most common intraocular cancer in adults, metastasizes to the liver in 90% of cases. Integrating DNA sequencing of 144 metastases with decade-long patient outcomes, we found that liver metastases are more enriched for BAP1-mutant, monosomy 3 clones, compared to extrahepatic metastases. BAP1 loss in liver metastases independently predicts poorer post-metastatic survival. Patterns of dissemination are set early in primary tumors, enabling molecular profiling to forecast metastatic spread.
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