Therapeutic Potential of Nutritional Modulators in Traumatic Brain Injury: A Systematic Review

Area of Science:

• Neuroscience
• Nutritional Science
• Biochemistry

Background:

• Traumatic brain injury (TBI) is a major global cause of death and disability.
• TBI induces oxidative stress and inflammation, worsening neurological deficits.
• Current treatments for secondary injury mechanisms in TBI are limited.

Purpose of the Study:

• To review the therapeutic potential of nutritional interventions for TBI.
• To synthesize evidence on vitamins, omega-3 fatty acids, and probiotics in TBI management.
• To evaluate preclinical and clinical findings on neuroprotection and recovery after TBI.

Main Methods:

• Systematic literature search of PubMed, Google Scholar, NIH, and The Nutrition Source.
• Inclusion of preclinical and clinical studies on TBI interventions.
• Adherence to PRISMA 2020 guidelines for study selection.

Main Results:

• Nutritional supplements exhibit anti-inflammatory and antioxidant properties.
• These interventions support synaptic plasticity and gut-brain axis integrity.
• Evidence suggests neuroprotective effects and neuronal repair mechanisms.

Conclusions:

• Preclinical data strongly support the neurotherapeutic potential of these supplements.
• Clinical validation for nutritional interventions in TBI is ongoing.
• Future research should focus on standardized protocols for effective integration into TBI care.