Related Experiment Video

Updated: Jan 27, 2026

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

6.3K

The Role of GDNF and NSE in Attention-deficit/Hyperactivity Disorder: The Relationship with Sleep and Eating

Sevgi Özmen1, Semiha Dursun2, Esra Demirci1

  • 1Department of Child and Adolescent Psychiatry, Erciyes University, Kayseri, Turkey.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|January 26, 2026
PubMed

Insights

Children with attention-deficit/hyperactivity disorder (ADHD) showed higher neuron-specific enolase (NSE) blood levels. Glial cell line-derived neurotrophic factor (GDNF) was linked to eating behaviors in these children.

Area of Science:

  • Neuroscience
  • Pediatric Psychiatry
  • Biomarkers

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a prevalent childhood psychiatric condition.
  • Understanding ADHD's biological underpinnings is crucial for effective diagnosis and treatment.
  • Biomarkers may offer objective measures for ADHD assessment.

Purpose of the Study:

  • To investigate serum levels of glial cell line-derived neurotrophic factor (GDNF) and neuron-specific enolase (NSE) in children with ADHD.
  • To explore the relationship between these biomarkers and ADHD symptoms, sleep patterns, and eating behaviors.
  • To identify potential biological markers differentiating ADHD from healthy controls.

Main Methods:

  • A case-control study involving 51 children diagnosed with ADHD and 20 healthy controls.
  • Assessment of sleep patterns using the Children's Sleep Habits Questionnaire.
  • Evaluation of eating behaviors via the Eating Behavior Assessment Scale for Children.
  • Quantification of serum GDNF and NSE levels using ELISA kits.

Main Results:

  • Serum NSE levels were significantly higher in the ADHD group compared to controls (p=0.038).
  • No significant difference in serum GDNF levels was observed between the groups (p=0.645).
  • A negative correlation was found between serum GDNF levels and eating behavior scores (r=-0.309, p=0.026).

Conclusions:

  • Elevated serum NSE may serve as a distinguishing biomarker for ADHD in children.
  • GDNF may play a role in regulating eating behaviors among children with ADHD.
  • Further research is warranted to elucidate the precise roles of GDNF and NSE in ADHD pathophysiology.
Abstract

Keywords:
Attention deficit disorder with hyperactivityEatingGlial cell line-derived neurotrophic factorPhosphopyruvate hydrataseSleep

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.3K
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis04:19

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis

Published on: May 10, 2022

4.4K

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
857
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
454
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
411
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.5K
Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.3K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
859