Related Experiment Video
Updated: Jan 27, 2026
Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
Combinatorial Therapy of Nanoformulation with Herbal Medicine to Circumvent Fungal Diseases
Abhay Kumar Singh1, Rupa Mazumder1, Anmol Dogra1
1Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida- Uttar Pradesh 201306, India.
Abstract:
Fungal infections now cause approximately 3.75 million deaths annually, nearly double previous estimates, and account for about 6.8% of all global deaths, surpassing those from tuberculosis and malaria combined. Fungal infections have become a greater worldwide health concern due to the emergence of drug-resistant forms, especially in immunocompromised people. Common drawbacks of conventional antifungal therapies include toxicity, low absorption, and resistance development. Low solubility, instability, and non-specific targeting are some of the reasons why conventional antifungal medicines usually show limited activity, resulting in less-than-ideal therapeutic outcomes and unfavorable side effects. A viable substitute is provided by combining nanotechnology with herbal medicine. Strong antifungal activities are found in natural bioactive chemicals found in herbal extracts. Encapsulated in nanocarriers, including metallic nanoparticles, liposomes, nanoemulsions, micelles, and ethosomes, these drugs exhibit improved solubility, stability, and targeted administration, which enhances therapeutic efficacy and decreases toxicity. According to studies, essential oils and polyphenolic chemicals work in concert to prevent fungal infections when they are encapsulated in nanocarriers. For example, fungal biofilms have been successfully penetrated by liposomal and transferosomal systems, which have been successful in getting beyond resistance mechanisms. Long-term drug release is made possible by lipid-based carriers and polymeric nanoparticles, which reduce side effects and improve patient compliance. To achieve the full potential of herbal-based nanoformulations in antifungal medication, future studies should concentrate on improving stability, refining formulation methods, and carrying out extensive clinical trials to confirm safety and efficacy. There is great potential for creating safer and more efficient medicines to fight multidrug-resistant fungal infections with this novel technique.
Insights
Nanotechnology combined with herbal medicine offers a promising solution to combat rising drug-resistant fungal infections. Herbal nanoformulations enhance drug delivery, improving efficacy and reducing side effects for better patient outcomes.
Area of Science:
- Mycology
- Nanomedicine
- Pharmacology
Background:
- Fungal infections cause significant global mortality, with drug-resistant strains posing a growing threat, especially to immunocompromised individuals.
- Conventional antifungal therapies suffer from limitations like toxicity, poor absorption, instability, and non-specific targeting, leading to suboptimal therapeutic results.
- The emergence of multidrug-resistant fungal pathogens necessitates the development of novel and effective treatment strategies.
Purpose of the Study:
- To explore the potential of combining nanotechnology with herbal medicine for enhanced antifungal therapy.
- To investigate how nanocarrier encapsulation improves the solubility, stability, and targeted delivery of natural bioactive compounds from herbal extracts.
- To evaluate the efficacy of herbal nanoformulations in overcoming drug resistance mechanisms and improving therapeutic outcomes.
Main Methods:
- Encapsulation of natural bioactive chemicals and essential oils from herbal extracts into various nanocarriers (e.g., metallic nanoparticles, liposomes, nanoemulsions, micelles, ethosomes).
- Utilizing lipid-based carriers and polymeric nanoparticles for controlled and long-term drug release.
- Employing liposomal and transferosomal systems to penetrate fungal biofilms and bypass resistance mechanisms.
Main Results:
- Herbal nanoformulations demonstrate significantly improved solubility, stability, and targeted administration compared to conventional antifungal drugs.
- Nanocarrier encapsulation enhances the antifungal activity of natural compounds, leading to increased therapeutic efficacy and reduced toxicity.
- Liposomal and transferosomal systems have shown success in penetrating fungal biofilms and overcoming drug resistance.
Conclusions:
- Combining nanotechnology with herbal medicine presents a viable and promising alternative for developing effective antifungal treatments.
- Herbal-based nanoformulations offer potential for safer and more efficient therapies against multidrug-resistant fungal infections.
- Future research should focus on enhancing formulation stability, refining methods, and conducting clinical trials to validate safety and efficacy.
More Related Videos
04:59Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
Published on: May 30, 2025
05:34Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
Published on: August 18, 2023
Related Concept Videos
02:33Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
00:59Gene Therapy
01:29Fungal Group Zygomycota
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:28Fungal Phylum Microsporidia