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Antagonistic interactions between CLAVATA receptors shape maize ear development.

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Summary
This summary is machine-generated.

Maize meristem maintenance involves the FASCIATED EAR 3 (FEA3) protein, which interacts with BARELY ANY MERISTEM 1D (BAM1D). Their antagonistic roles in inflorescence meristem size reveal complex CLAVATA signaling interactions.

Keywords:
CLAVATALRR receptordevelopmental biologyinflorescence developmentmaizemeristemproximity labeling

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Area of Science:

  • Plant biology
  • Molecular genetics
  • Developmental biology

Background:

  • Meristem activity is regulated by the CLAVATA (CLV) signaling pathway, involving leucine-rich repeat (LRR) receptors and CLV-EMBRYO SURROUNDING REGION (CLE) peptides.
  • FASCIATED EAR 3 (FEA3), an LRR receptor-like protein, is crucial for maize meristem maintenance and functions independently of canonical CLV receptors.

Purpose of the Study:

  • To elucidate the interaction network of FEA3 in maize meristems.
  • To identify novel components of the CLV signaling pathway and understand their roles in meristem regulation.

Main Methods:

  • Utilized TurboID-based proximity labeling in Zea mays meristems to identify FEA3's interacting partners.
  • Performed genetic analysis to determine the epistatic and antagonistic relationships between FEA3 and BARELY ANY MERISTEM 1D (BAM1D).

Main Results:

  • Identified BARELY ANY MERISTEM 1D (BAM1D) as a putative co-receptor interacting with FEA3.
  • Over 40 shared proteins were identified in FEA3 and BAM1D proximity labeling proteomes, indicating convergence on a common signaling pathway.
  • FEA3 and BAM1D exhibit antagonistic roles in inflorescence meristem size control, with fea3 mutants showing larger meristems and bam1d mutants showing smaller meristems.

Conclusions:

  • In vivo TurboID-based proximity labeling effectively clarifies complex genetic interactions within CLV signaling pathways.
  • FEA3 and BAM1D physically interact and antagonistically regulate maize inflorescence meristem size.
  • Multiple, partially overlapping CLV receptor complexes coordinate meristem maintenance, expanding knowledge of downstream signaling components.