Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

2.1K
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
2.1K
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

41.1K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
41.1K
Correlations02:20

Correlations

35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Correlation and Causation01:27

Correlation and Causation

42.4K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
Mismatch Repair01:36

Mismatch Repair

43.6K
Overview
43.6K
Overview of DNA Repair02:25

Overview of DNA Repair

33.5K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Race and Cerebrospinal Fluid Leaks: Concerning Associations after Endonasal Transsphenoidal Pituitary Resection.

Journal of neurological surgery. Part B, Skull base·2026
Same author

Long-Term Opioid Use After Treatment of Head and Neck Cancers: A Systematic Review and Meta-analysis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2025
Same author

Characterization of Hearing Loss in Paget Disease: A National Database Study.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2025
Same author

Exploring Demographic Associations of Patient-Reported Psychological Barriers to Bell's Palsy Care.

Facial plastic surgery & aesthetic medicine·2025
Same author

Complex Salvage Lower Lip Reconstruction Using Gracilis Free Flap.

Facial plastic surgery & aesthetic medicine·2025
Same journal

Otovent Versus Valsalva: Physiological Insights for Diagnostic and Therapeutic Autoinflation in Eustachian Tube Dysfunction.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

CSNK1A1 Mediates Inner Ear Inflammation and Endolymphatic Hydrops in a Lipopolysaccharide-Induced Mouse Model.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Medial Flap Versus Coblation-Assisted Turbinoplasty For Turbinates Hypertrophy: A Prospective Randomized Controlled Trial.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Ethical Considerations in Using the Pernkopf Atlas in Otolaryngology Education Ethics in Practice: Point-Counterpoint.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K

Optimal Timing of Cleft Lip Repair: Correlation With Scar Formation and Revision Rates.

Jamil Hayden1,2, Christopher L Crafton1, Julia Keating3

  • 1Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

Performing cleft lip repair (CLR) earlier, before 3 months, reduces hypertrophic scarring but increases the need for revision surgery. This timing trade-off impacts surgical planning for infants with cleft lip.

Keywords:
cleft lipfacial plastic surgeryhypertrophic scaroutcomes researchpediatric otolaryngologyrevision surgerytiming of surgerywound healing

More Related Videos

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
12:19

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS

Published on: October 7, 2009

27.7K
Intermediate Strain Rate Material Characterization with Digital Image Correlation
07:59

Intermediate Strain Rate Material Characterization with Digital Image Correlation

Published on: March 1, 2019

7.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

3.3K
Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS
12:19

Antibody Profiling by Luciferase Immunoprecipitation Systems LIPS

Published on: October 7, 2009

27.7K
Intermediate Strain Rate Material Characterization with Digital Image Correlation
07:59

Intermediate Strain Rate Material Characterization with Digital Image Correlation

Published on: March 1, 2019

7.6K

Area of Science:

  • Plastic Surgery
  • Pediatric Surgery
  • Otolaryngology

Background:

  • Hypertrophic scarring (HTS) and the need for revision surgery are common concerns following cleft lip repair (CLR).
  • The optimal timing for primary CLR to minimize these outcomes remains debated.

Purpose of the Study:

  • To investigate the association between earlier timing of primary CLR and the incidence of HTS and subsequent revision surgery.
  • To evaluate the clinical implications of early cleft lip repair (ECLR) versus traditional cleft lip repair (TLR) on scar formation and reoperation rates.

Main Methods:

  • A retrospective cohort study utilizing the TriNetX Analytics Network, a de-identified healthcare data network.
  • Infants undergoing primary CLR before one year of age were classified into early (ECLR, <3 months) and traditional (TLR, 3-12 months) groups.
  • Propensity score matching was employed to control for confounding variables, followed by statistical comparison of HTS and revision surgery rates.

Main Results:

  • A total of 6786 infants were analyzed, with 4321 in the ECLR group and 2465 in the TLR group.
  • The incidence of HTS was significantly lower in the ECLR group (3.2%) compared to the TLR group (5.2%, P=.002).
  • Conversely, revision surgery was more frequent after ECLR (6.6%) than TLR (2.6%, P<.001), with these findings persisting post-matching.

Conclusions:

  • Early cleft lip repair (<3 months) is associated with a reduced risk of hypertrophic scarring.
  • However, earlier repair correlates with an increased requirement for subsequent revision surgery.
  • These results highlight a critical trade-off in timing decisions for CLR, informing surgical planning and patient counseling.