Related Experiment Video
Updated: Jan 27, 2026

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches
Published on: October 18, 2024
[Exercise-induced hyperinsulinism: genetic basis and clinical management]
1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology/Hubei Provincial Key Laboratory of Pediatric Genetic Metabolic and Endocrine Rare Diseases/Hubei Provincial Clinical Research Center for Children's Growth and Development and Metabolic Diseases, Wuhan 430030, China.
Exercise-induced hyperinsulinism, a rare condition from SLC16A1 gene variants, causes low blood sugar during exercise. This review covers its genetics, diagnosis, and treatment for better clinical understanding.
Area of Science:
- Endocrinology
- Genetics
- Metabolic Disorders
Background:
- Exercise-induced hyperinsulinism (EIH) is a rare congenital hyperinsulinism subtype.
- It results from gain-of-function variants in the SLC16A1 gene, encoding monocarboxylate transporter 1.
- Fewer than 20 cases are documented, highlighting its rarity.
Purpose of the Study:
- To systematically review the genetic pathogenesis of EIH.
- To summarize current diagnostic approaches for EIH.
- To outline established and emerging treatments for EIH.
Main Methods:
- Systematic literature review.
- Analysis of genetic variants in SLC16A1.
- Compilation of reported clinical cases, diagnostic criteria, and treatment outcomes.
Main Results:
- Gain-of-function variants in SLC16A1 are the primary cause of EIH.
- Diagnosis relies on clinical presentation, genetic testing, and response to fasting/exercise challenges.
- Treatment strategies vary, including dietary management and medical therapies.
Conclusions:
- EIH requires specialized diagnostic and management strategies.
- Further research is needed to elucidate the full spectrum of SLC16A1 variants and optimize treatment.
- Improved understanding can enhance clinical recognition and patient care.
Related Concept Videos
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Acute Pancreatitis II: Clinical Manifestations and Management
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

