Related Experiment Video

Updated: Jan 28, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
12:16

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

15.5K

Pre-discharge car seat tolerance screening in infants with CHD: a single-centre review

Nicholas V Barresi1, Mary D Schiff2, Frederick Roberts2

  • 1Division of Pediatric Cardiology, https://ror.org/03763ep67Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

Cardiology in the Young
|January 26, 2026
PubMed

Insights

Infants with congenital heart disease (CHD) have a higher car seat screening failure rate than premature infants. DiGeorge Syndrome was the only comorbidity linked to failure, which can delay hospital discharge.

Area of Science:

  • Pediatrics
  • Cardiology
  • Neonatal Care

Background:

  • Infants with congenital heart disease (CHD) require careful assessment before discharge.
  • Car seat tolerance screening is crucial for infant safety, but data on CHD populations is limited.

Purpose of the Study:

  • To determine the car seat screening failure rate in infants with CHD.
  • To identify clinical factors associated with car seat test failure.
  • To assess the impact of failed car seat tests on hospital discharge.

Main Methods:

  • A retrospective study of 193 infants with CHD was conducted.
  • Infants were discharged from a general cardiology service.
  • Statistical analyses compared characteristics between infants who passed and failed car seat testing.

Main Results:

  • The car seat test failure rate was 6.2%.
  • No significant differences were found in birthweight, prematurity, or cardiac physiology between passing and failing groups.
  • DiGeorge Syndrome was the only comorbidity significantly associated with a higher failure rate (25.0% vs 2.2%).
  • A failed test delayed hospital discharge by a median of 1.5 days.

Conclusions:

  • The car seat test failure rate in infants with CHD is higher than in premature infants.
  • Cardiac physiology did not correlate with car seat test failure.
  • DiGeorge Syndrome is a key comorbidity associated with car seat test failure in this population.
  • Failed car seat tests can prolong hospital stays.
Abstract

Keywords:
Paediatric Acute Care Cardiology Collaborative (PAC3)Paediatric Cardiac Critical Care Consortium (PC4)car seat testhospital dischargeneonate

More Related Videos

Defining the Role Of Language in Infants' Object Categorization with Eye-tracking Paradigms07:31

Defining the Role Of Language in Infants' Object Categorization with Eye-tracking Paradigms

Published on: February 8, 2019

7.3K
P50 Sensory Gating in Infants12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K

Related Concept Videos

Discharge Summary Forms01:31

Discharge Summary Forms

The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
1.3K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.1K
RC Circuits: Discharging A Capacitor01:27

RC Circuits: Discharging A Capacitor

One of the applications of an RC circuit is the relaxation oscillator. The relaxation oscillator comprises a voltage source, a capacitor, a resistor, and a neon lamp. The lamp acts like an open circuit (infinite resistance) until the potential difference across the neon lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit (zero resistance), and the capacitor discharges through the neon lamp and produces light. Once the capacitor is fully discharged through the...
4.4K
pre-mRNA Processing02:01

pre-mRNA Processing

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
57.4K
Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
14.7K