TREAT-AIS: A Multicenter National Registry

Area of Science:

• Neurology
• Cardiovascular Diseases
• Public Health

Background:

• Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke due to large-artery occlusion.
• The Taiwan Stroke Society initiated the nationwide TREAT-AIS registry in January 2019 to track EVT outcomes.
• This registry captures real-world data on EVT procedures and patient outcomes in Taiwan.

Purpose of the Study:

• To present the study design, progress, and baseline data of the TREAT-AIS registry.
• To analyze the effectiveness of EVT in achieving functional independence at 3 months post-stroke.
• To investigate the influence of sex on post-EVT outcomes in acute ischemic stroke patients.

Main Methods:

• A multicenter prospective registration program involving patients aged 20 years or older undergoing EVT for acute ischemic stroke.
• Data collection included general stroke demographics and EVT-specific details.
• Functional independence (modified Rankin Scale score 0-2) at 3 months was the primary effectiveness outcome; sex differences were analyzed.

Main Results:

• 1522 patients were enrolled by June 2022 across 19 medical centers.
• The median NIH Stroke Scale score was 18; cardioembolism was the most common stroke cause (43.6%).
• Functional independence was achieved in 36.2% of patients; initial male advantage diminished after adjusting for age, stroke severity, and recanalization.

Conclusions:

• The TREAT-AIS registry is effectively capturing real-world EVT data in Taiwan.
• The registry provides valuable insights into EVT practices and quality of care for acute stroke patients in an Asian population.
• Further analysis will elucidate factors influencing EVT outcomes in this cohort.