Related Experiment Video

Updated: Jan 28, 2026

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.4K

COVID-19 Affects Short-Term, But Not 90-Day, Outcome in Patients With Stroke Treated With Mechanical Thrombectomy

Niklas M Beckonert1,2, Felix J Bode1, Franziska Dorn3

  • 1Division of Vascular Neurology Department of Neurology University Hospital Bonn Bonn Germany.

Stroke (Hoboken, N.J.)
|January 26, 2026
PubMed

Insights

COVID-19 negatively impacts short-term stroke recovery in patients undergoing endovascular treatment (ET). However, long-term functional outcomes at 90 days remain similar, suggesting ET should not be withheld.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Research

Background:

  • COVID-19 is linked to increased stroke incidence and poorer outcomes.
  • Patients with large-vessel occlusion stroke and COVID-19 receiving endovascular treatment (ET) experienced worse discharge outcomes.
  • The long-term functional impact of COVID-19 in these patients requires further investigation.

Purpose of the Study:

  • To assess the effect of COVID-19 on 90-day functional outcomes in patients with large-vessel occlusion stroke treated with ET.
  • To compare outcomes between patients with and without concomitant COVID-19.

Main Methods:

  • Analysis of the German Stroke Registry-Endovascular Treatment (GSR-ET) database.
  • Propensity score matching (1:4) of patients with and without COVID-19.
  • Multivariable ordinal regression analysis to evaluate functional outcomes at 90 days.

Main Results:

  • 72 (1.8%) of 4010 patients had COVID-19 during ET.
  • COVID-19 patients showed higher NIHSS scores at 24 hours and worse discharge scores (NIHSS and mRS).
  • Despite short-term deficits, 90-day functional outcomes (mRS) were similar between groups (P=0.34).

Conclusions:

  • COVID-19 adversely affects short-term functional outcomes post-ET for large-vessel occlusion stroke.
  • Long-term (90-day) functional outcomes are not significantly impacted by COVID-19.
  • Endovascular treatment should be considered for eligible patients irrespective of COVID-19 status.
Abstract

Keywords:
COVID‐19clinical outcomeendovascular treatmentmechanical thrombectomystroke

More Related Videos

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

2.6K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K

Related Concept Videos

Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.3K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Reaction Mechanisms03:06

Reaction Mechanisms

Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.7K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K