6-[(4-Methylphenyl)sulfonylamino]hexanoic acid: MAK Value Documentation - Translation of the German version from...

The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has evaluated the occupational exposure limit value (maximum concentration at the workplace, MAK value) of 6-[(4-methylphenyl)sulfonylamino]hexanoic acid (N-tosyl-6-aminocaproic acid) [78521-39-8] considering all toxicological end points. Relevant studies were identified from a literature search and also unpublished study reports were used. The substance is a complexing agent. As the influence of the complexing effect and the acid effect on the respiratory tract is not known and inhalation studies are not available, a maximum concentration at the workplace (MAK value) cannot be derived. The NOAEL for developmental effects in rats after oral administration was 100 mg/kg body weight and day. In a gavage study in rats that was carried out according to OECD Test Guideline 422, pup mortality was increased and pup body weights were decreased up to postnatal day 4 at 1600 mg/kg body weight and day. The substance is not genotoxic in bacteria or mammalian cells. Carcinogenicity studies are not available. There is no evidence of a contact sensitizing potential. Skin contact is not expected to contribute significantly to systemic toxicity.