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Updated: Jan 27, 2026

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An Efficient Method to Obtain Dedifferentiated Fat Cells
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Dedifferentiated Liposarcoma With Low-Grade Osteosarcomatous Differentiation: A Rare Case With Long-Term Imaging
Kanae Takahashi1, Takuya Adachi1, Yuki Funauchi2
1Department of Diagnostic Radiology and Nuclear Medicine, Institute of Science Tokyo, Tokyo, JPN.
Cureus
|January 26, 2026
Summary
Dedifferentiated liposarcoma (DDLPS) with osteosarcomatous differentiation is rare but carries a high recurrence risk. Gradual calcification growth in lipomas may signal this aggressive DDLPS subtype, aiding early diagnosis.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Dedifferentiated liposarcoma (DDLPS) is a rare soft tissue sarcoma.
- DDLPS with low-grade osteosarcomatous differentiation presents unique diagnostic challenges.
- This subtype is associated with a higher risk of early local recurrence compared to DDLPS without osteogenic features.
Keywords:
computed tomographydedifferentiated liposarcomamagnetic resonance imagingorthopaedic oncologyosteosarcomatous differentiationMore Related Videos
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