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Once-Weekly Semaglutide Is Associated With Improvement in Vascular Endothelial Function in Patients With Type 2
Seigo Sugiyama1, Akira Yoshida1, Noboru Kurinami1
1Diabetes Care Center, Jinnouchi Hospital, Kumamoto, JPN.
Cureus
|January 26, 2026
Summary
Weekly semaglutide improved vascular endothelial function in Japanese patients with type 2 diabetes. This GLP-1 receptor agonist may offer cardiovascular protection in T2DM management.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Type 2 diabetes mellitus (T2DM) patients face high cardiovascular disease (CVD) risk.
- Lower circulating glucagon-like peptide-1 (GLP-1) levels are observed in Japanese patients with coronary artery disease (CAD).
- Once-weekly semaglutide, a GLP-1 receptor agonist, shows cardiometabolic benefits, but its vascular endothelial function effects in Japanese T2DM patients are unclear.
Purpose of the Study:
- To evaluate the effect of once-weekly semaglutide on vascular endothelial function in Japanese patients with T2DM.
- To assess changes in clinical parameters including body weight, HbA1c, LDL-cholesterol, and hsCRP.
Main Methods:
- Retrospective observational study of 24 Japanese T2DM patients initiated on once-weekly subcutaneous semaglutide.
- Vascular endothelial function assessed via reactive hyperemia peripheral arterial tonometry (RHI) pre- and post-treatment.
- Evaluated changes in body weight (BW), glycated hemoglobin A1c (HbA1c), low-density lipoprotein cholesterol (LDL-cho), and high-sensitivity C-reactive protein (hsCRP).
Main Results:
- Semaglutide treatment significantly increased RHI (p<0.01), indicating improved vascular endothelial function.
- Significant reductions observed in BW, HbA1c, and LDL-cho (all p<0.01).
- HsCRP showed a non-significant decreasing trend; no correlation found between clinical parameter changes and RHI changes.
Conclusions:
- Once-weekly semaglutide significantly improved vascular endothelial function in Japanese T2DM patients.
- Results support a potential cardiovascular protective role for semaglutide in T2DM management.
- Further research is warranted to explore the mechanisms and long-term benefits.
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