Two Siblings With Microcephalic Osteodysplastic Primordial Dwarfism Type II (MOPDII) Caused by Compound Heterozygous

Ahmed Al Farsi1,2,3, Lina Abdullah3,2, Amr Khalil2

  • 1Pediatrics, NICU, London Health Sciences Centre, London, CAN.

Cureus
|January 26, 2026
PubMed
Summary

Microcephalic osteodysplastic primordial dwarfism type II (MOPDII) is a rare genetic disorder. This study presents two male siblings with MOPDII, highlighting compound heterozygous inheritance and the need for early diagnosis in severe growth restriction.

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