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Related Experiment Video

Updated: Jan 28, 2026

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
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Factors Contributing to Achilles Tendon Re-rupture: A Systematic Review.

Abimbola O Kolawole1, Temidun O Kolawole2, Robert H Ablove3

  • 1Medicine, Central Michigan University College of Medicine, Mount Pleasant, USA.

Cureus
|January 26, 2026
PubMed
Summary

Factors influencing Achilles tendon re-rupture are complex. This review found no single superior treatment, with early functional rehabilitation not clearly linked to increased re-rupture risk in acute Achilles tendon rupture (ATR).

Keywords:
achilles ruptureachilles tendinopathypreventative measuresre-rupturesports participation

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Area of Science:

  • Orthopedics
  • Sports Medicine
  • Rehabilitation Science

Background:

  • Acute Achilles tendon rupture (ATR) is a common injury in active adults.
  • Predictors of re-rupture after ATR are inconsistently reported due to varied study designs and outcome definitions.

Purpose of the Study:

  • To systematically review treatment strategies and patient factors associated with Achilles tendon re-rupture.
  • To provide a narrative synthesis of evidence due to substantial heterogeneity in existing studies.

Main Methods:

  • Systematic search of PubMed, Web of Science, CINAHL, and Cochrane Library (2004-2024) following PRISMA 2020 guidelines.
  • Inclusion of studies reporting re-rupture after acute ATR in adults, evaluating baseline characteristics, treatments, or rehabilitation.
  • Narrative synthesis of data and descriptive reporting of numerical ranges due to heterogeneity; quality assessment using NIH tools.

Main Results:

  • Eleven studies (44,557 patients) were included, showing wide variations in re-rupture rates across treatments.
  • No single repair method was consistently superior; specific techniques like Tenolig had higher rates in small, non-randomized studies.
  • Early weight-bearing and functional rehabilitation showed no clear association with increased re-rupture, though protocols varied.

Conclusions:

  • Achilles tendon re-rupture is multifactorial, involving patient and treatment characteristics.
  • Current evidence does not favor one contemporary repair strategy over another for ATR.
  • Early functional rehabilitation appears safe when implemented within structured protocols, but consistent reporting is needed for future research.