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Targeting Dermatologic Side Effects of Immunotherapy Using Novel Skin Care Products
Marithé Claes1,2, Joy Lodewijckx1,2, Jolien Robijns1,2
1Hasselt University, Faculty of Medicine and Life Sciences, Agoralaan, 3590 Diepenbeek, Belgium / LCRC.
Journal of Cancer
|January 26, 2026
Summary
Novel emollients significantly reduced skin toxicity and improved quality of life for patients undergoing immunotherapy. This skincare intervention demonstrated high patient satisfaction and a strong likelihood of recommendation.
Area of Science:
- Oncology
- Dermatology
- Patient Care
Background:
- Immunotherapy often causes cutaneous adverse events (skin toxicities).
- These skin toxicities can negatively impact patients' quality of life (QoL).
Purpose of the Study:
- To evaluate the efficacy of two novel skin care products.
- To assess their role in preventing and managing immunotherapy-related skin toxicities.
Main Methods:
- An open-label, single-group study involving 75 cancer patients undergoing immunotherapy.
- Patients applied novel emollients daily for three weeks.
- Skin toxicity was assessed using NCI-CTCAE v5.0, with patient-reported outcomes measured via questionnaires (NRS, DLQI, Skindex-29).
Main Results:
- Pruritus and xerosis were the most common toxicities, showing significant improvement (P<0.001) with emollient use.
- Patient-reported symptoms, Skindex-29 scores (P<0.001), and DLQI (P=0.038) significantly improved.
- High patient satisfaction (70.7%) and recommendation rates (74.6%) were reported.
Conclusions:
- The novel emollients effectively alleviated immunotherapy-related dermatological toxicities.
- This led to an improvement in patient quality of life, satisfaction, and likelihood of recommendation.
- Further research with a control group is recommended for definitive conclusions.
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