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Iris RESTful Server and IrisTileSource: An Iris implementation for existing OpenSeaDragon viewers
Ryan Erik Landvater1, Navin Kathawa1, Mustafa Yousif1
1University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.
Journal of Pathology Informatics
|January 26, 2026
Summary
The Iris RESTful Server improves whole-slide image (WSI) viewing by enabling native streaming of Iris File Extension (IFE) files. This high-performance solution integrates with OpenSeaDragon, simplifying WSI workflows for pathologists and administrators.
Area of Science:
- Digital Pathology
- Medical Imaging Informatics
- Computer Science
Background:
- Whole-slide imaging (WSI) file formats like Iris File Extension (IFE) require efficient streaming for pathology applications.
- Traditional HTTP servers struggle with natively streaming subregions of high-resolution WSI files.
- Current WSI viewers often convert files to Deep Zoom Images (DZI) for compatibility, limiting functionality.
Purpose of the Study:
- To develop a low-overhead, high-performance HTTP server for native IFE file streaming.
- To create a RESTful API compatible with DICOMweb WADO-RS for seamless integration.
- To enhance WSI viewer systems with improved rendering and management capabilities.
Main Methods:
- Developed the Iris RESTful Server using C++, Boost Beast HTTP, and Asio networking libraries.
- Implemented native compatibility with the DICOMweb WADO-RS API.
- Created and merged a new OpenSeaDragon TileSource compatible with the Iris RESTful API.
Main Results:
- The Iris RESTful Server demonstrates high performance, handling an average of 3883 requests/second with a median latency of 21ms on minimal hardware.
- A new OpenSeaDragon TileSource enables direct integration, replacing DZI conversions.
- The server functions as a secure, cross-origin resource sharing microservice.
Conclusions:
- The Iris RESTful Server provides a secure, high-performance solution for streaming WSI files, enhancing digital pathology workflows.
- This architecture simplifies WSI management and improves the user experience for pathologists.
- The open-source availability accelerates the development and adoption of advanced WSI web viewers.
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