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Updated: Jan 28, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Systemic light chain cardiac amyloidosis with atrioventricular block
1Department of Cardiology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Systemic light-chain amyloidosis (AL) patients may experience delayed cardiac events despite treatment. Continuous monitoring with an implantable cardiac monitor is crucial for detecting life-threatening arrhythmias and guiding pacemaker implantation.
Area of Science:
- Cardiology
- Hematology
- Electrophysiology
Background:
- Systemic light-chain (AL) amyloidosis is a rare plasma cell disorder.
- Cardiac involvement is common (60-75%), with poor prognosis without treatment.
- Atrioventricular (AV) conduction block affects 3-5% of AL patients.
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