Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.7K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.7K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.5K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.5K
Sternberg's Triangular Theory of Love02:15

Sternberg's Triangular Theory of Love

45.8K
We typically love the people with whom we form relationships, but the type of love we have for our family, friends, and lovers differs. Robert Sternberg (1986) proposed that there are three components of love: intimacy, passion, and commitment. These three components form a triangle that defines multiple types of love: this is known as Sternberg’s triangular theory of love. Intimacy is the sharing of details and intimate thoughts and emotions. Passion is the physical attraction—the...
45.8K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.2K
Rectangular and Triangular Pulse Function01:19

Rectangular and Triangular Pulse Function

1.9K
The unit rectangular pulse function is mathematically represented by a rectangular function centered at the origin with a height of one unit. This function is defined by two parameters: T, which specifies the center location of the pulse along the time axis, and Ï„, which determines the pulse duration.
For example, consider a rectangular pulse with a 5V amplitude, a 3-second duration, and centered at t=2 seconds. This pulse can be expressed using the rectangular function, written as,
1.9K
Network Covalent Solids02:18

Network Covalent Solids

16.1K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test-retest reliability of Wagner Pressure algometer in measuring pain Pressure threshold in patients with chronic neck pain: repeated-measures reliability study.

The Journal of manual & manipulative therapy·2026
Same author

Effectiveness of lateral pterygoid muscle energy technique in patients with temporomandibular joint dysfunction: a randomized controlled trial.

Physiotherapy theory and practice·2025
Same author

Efficacy of branched chain amino acid administration on cognitive function: a systematic review.

Nutritional neuroscience·2025
Same journal

Global burden of metabolic dysfunction-associated steatotic liver disease attributable to tobacco, 1990-2023, and projected trends to 2038.

Journal of diabetes and metabolic disorders·2026
Same journal

The association of the TyG index-related parameters and bone health status in men aged 50 and over: a cross-sectional analysis of Bushehr Elderly Health (BEH) program.

Journal of diabetes and metabolic disorders·2026
Same journal

Population attributable fraction of cardiovascular disease, coronary heart disease, and stroke associated with insufficient non-occupational physical activity in Iranian adults: findings from the STEPS 2021 survey.

Journal of diabetes and metabolic disorders·2026
Same journal

Impact of obesity and type 2 diabetes on muscle power, quality, and force-velocity, and their relation to functional capacity.

Journal of diabetes and metabolic disorders·2026
Same journal

Clarification of poor adherence to treatment among patients with type 2 diabetes in Iran: the magnitude of the problem and the its determinants.

Journal of diabetes and metabolic disorders·2026
Same journal

Are diabetologists against metabolic surgery?

Journal of diabetes and metabolic disorders·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K

Gut microbiota, sarcopenia, and type 2 diabetes: a triangular pathophysiological network.

Firdaus Jawed1, Rabia Aziz1, Sajad Ul Islam Mir2

  • 1Department of Physiotherapy, Jamia Hamdard, Room Number 522, 5th floor, Central Library Building, New Delhi, 110062 India.

Journal of Diabetes and Metabolic Disorders
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes mellitus (T2DM) and sarcopenia are linked to gut microbiota dysbiosis. Interventions targeting this gut-muscle-metabolism axis, including diet and probiotics, show promise for managing these interconnected conditions.

Keywords:
DysbiosisGut microbiotaMuscle healthProbioticsSarcopeniaShort-chain fatty acidsType 2 diabetes

More Related Videos

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.0K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K

Related Experiment Videos

Last Updated: Jan 28, 2026

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.0K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.8K

Area of Science:

  • Metabolic Health
  • Microbiome Research
  • Musculoskeletal Disorders

Background:

  • Type 2 diabetes mellitus (T2DM), sarcopenia, and gut microbiota dysbiosis are increasingly recognized as interrelated conditions.
  • T2DM accelerates muscle wasting via insulin resistance and inflammation, while sarcopenia exacerbates metabolic dysfunction.
  • These conditions form a triangular pathophysiological network impacting metabolic and musculoskeletal health.

Purpose of the Study:

  • To review the interconnectedness of T2DM, sarcopenia, and gut microbiota dysbiosis.
  • To explore the therapeutic potential of interventions targeting this triad.
  • To highlight the need for integrated strategies for metabolic and musculoskeletal health.

Main Methods:

  • Extensive literature search in PubMed, EMBASE, Scopus, and Web of Science up to July 2025.
  • Inclusion of preclinical and human studies examining microbial composition, metabolites, inflammation, insulin resistance, and muscle protein turnover.
  • Focus on bidirectional relationships and mechanistic links between the conditions.

Main Results:

  • T2DM patients exhibit higher sarcopenia prevalence; reduced muscle mass increases T2DM risk.
  • Gut dysbiosis in T2DM involves depleted SCFA-producers and enriched endotoxin-producers, causing inflammation and insulin resistance.
  • Preclinical and clinical studies show muscle atrophy in germ-free/antibiotic-treated models, with muscle/metabolic improvements from probiotics/prebiotics.

Conclusions:

  • T2DM, sarcopenia, and gut microbiota are linked via insulin resistance, inflammation, and altered signaling.
  • Targeting the gut-muscle-metabolism axis through diet, microbiota modulation, and exercise is a promising therapeutic strategy.
  • Further longitudinal and interventional studies are crucial for establishing causality and developing precision microbiome-based therapies.