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Updated: Jan 28, 2026
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Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
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Cell characterization of extranodal lymphoproliferative disorders
Priyadharshini Muthumanickam1, Pratibha Ramani1
1Department of Oral Pathology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|January 26, 2026
Summary
This study analyzed intraoral extranodal lymphoproliferative disorders (LPDs), finding Non-Hodgkin lymphoma most common. Centroblasts were key in aggressive cases, highlighting the need for precise diagnosis and targeted therapies.
Area of Science:
- Oral Pathology
- Hematology
- Oncology
Background:
- Lymphoproliferative disorders (LPDs) involve abnormal lymphocyte proliferation.
- Extranodal LPDs, especially in the oral cavity, are rare.
- Understanding histopathological and immunophenotypic features is crucial for diagnosis and management.
Purpose of the Study:
- Evaluate cellular composition of intraoral extranodal LPDs.
- Assess the diagnostic significance of these cellular components.
- Correlate findings with clinical and immunohistochemical data.
Main Methods:
- Retrospective analysis of 14 intraoral extranodal LPD cases (2004-2024).
- Review of clinical records, histopathology, and immunohistochemistry.
- Focus on cellular components like centroblasts, centrocytes, immunoblasts, and plasma cells.
Main Results:
- Non-Hodgkin lymphoma (NHL) accounted for 74% of cases.
- Maxilla was more frequently affected (8:2 ratio).
- Centroblasts were the most prominent cell type (38%), associated with diffuse growth patterns.
Conclusions:
- Intraoral extranodal LPDs have distinct diagnostic features.
- Centroblast predominance indicates aggressive disease and prognostic value.
- Multidisciplinary approach and molecular marker research are vital for improved outcomes.
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