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Recent technological advancements have revolutionized arteriovenous malformation (AVM) modeling, moving beyond traditional methods to incorporate 3D printing and advanced imaging for better treatment testing and analysis.

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Area of Science:

  • Neurosurgery
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins, bypassing capillary circulation.
  • Early research by Hunter, Virchow, and Luschka laid the foundation for understanding AVMs, particularly cerebral AVMs.
  • Traditional AVM models often relied on animal studies or anatomical analysis before recent technological shifts.

Purpose of the Study:

  • To review the evolution and current state of arteriovenous malformation (AVM) models in scientific literature.
  • To analyze the impact of recent technological innovations on the development of novel AVM modeling techniques.

Main Methods:

  • A comprehensive PubMed search was conducted using keywords 'brain,' 'arteriovenous malformation,' and 'model.'
  • 489 articles were identified, and after screening, 41 were selected for detailed review.
  • The review focused on advancements in vascular modeling over the last decade.

Main Results:

  • Technological innovations, including 3D flow models and 4D flow MRI, have significantly advanced AVM modeling.
  • Developments in preservation solutions, catheterization, and imaging have enabled new models like the cerebrovascular placental model.
  • These novel models facilitate testing of various AVM treatments, including radiosurgery and embolization.

Conclusions:

  • The field of AVM modeling has undergone a technological revolution in the past decade.
  • Current models offer sophisticated platforms for evaluating AVM treatments and understanding disease pathology.
  • This review synthesizes the breadth of AVM models reported over the last five decades.