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AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework
Mayerly Prada Rico1, Jaime Fernández-Sarmiento2,3, Maria Jose Santiago4
1Department of Pediatrics and Pediatric Nephrology, Universidad del Bosque, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
Frontiers in Pediatrics
|January 26, 2026
Summary
Continuous renal replacement therapy (CRRT) is challenging in infants under 10kg. The AEIOU strategy offers a structured framework to improve the safety and effectiveness of CRRT in this vulnerable pediatric population.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Neonatology
Background:
- Continuous renal replacement therapy (CRRT) is vital for critically ill children with acute kidney injury (AKI) and fluid overload.
- CRRT in neonates and infants (<10kg) presents unique challenges including limited blood volume, hemodynamic instability, and lack of specialized devices.
- While newer technologies improve feasibility, suboptimal survival outcomes and lack of standardized guidelines persist in this population.
Purpose of the Study:
- To introduce the AEIOU strategy, a novel educational and practical framework designed to simplify and organize essential components for safe and effective CRRT in infants under 10kg.
- To provide a structured mnemonic to aid clinical teams in implementing and managing CRRT in small infants.
- To enhance quality of care, facilitate training, and establish a foundation for future collaborative research in pediatric CRRT.
Main Methods:
- Development of the AEIOU mnemonic: A (Alerts), E (Execution Team), I (Inputs), O (Orders), U (Unified Record).
- Integration of existing literature and clinical experience into a practical framework.
- Focus on key CRRT components: indications, risks, team, equipment, prescription, and documentation.
Main Results:
- The AEIOU strategy provides a structured, reproducible mnemonic for CRRT implementation in infants.
- It addresses critical aspects from initial assessment to outcome monitoring.
- The framework is designed for adaptability to other extracorporeal therapies in pediatrics.
Conclusions:
- The AEIOU strategy offers a simple, comprehensive guide to improve CRRT implementation, education, and outcome monitoring in neonates and small infants.
- Standardized documentation and a structured approach are crucial for improving care in this high-risk group.
- This framework has the potential to enhance CRRT delivery and research in pediatric critical care.
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