Related Experiment Video

Updated: Jan 28, 2026

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
13:50

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat

Published on: February 5, 2011

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Long-Term Stability of Patients Undergoing Endovascular Parent Artery Occlusion of Their Intracranial Artery

Satoshi Koizumi1, Masaaki Shojima2, Takahiro Ota3

  • 1Department of Neurosurgery The University of Tokyo Bunkyo-ku Tokyo Japan.

Stroke (Hoboken, N.J.)
|January 26, 2026
PubMed

Insights

Parent artery occlusion (PAO) is a viable treatment for intracranial arteries, showing stable mid- to long-term outcomes. The risk of late stroke and new aneurysm formation is low after PAO.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Interventional Radiology

Background:

  • Endovascular parent artery occlusion (PAO) is a recognized treatment for intracranial arteries.
  • Long-term stability of cerebral blood flow after PAO remains a concern.

Purpose of the Study:

  • To evaluate the long-term clinical and radiological outcomes of patients who underwent endovascular PAO.

Main Methods:

  • Observational study of 104 patients undergoing PAO of internal carotid or vertebral arteries (VA) between April 2011 and March 2022.
  • Data collected on patient characteristics, endovascular treatment details, and clinical/radiological follow-up.

Main Results:

  • PAO was successful in all cases. Early stroke occurred in 31.7% of cases, primarily ischemic stroke in VA PAO.
  • Over a mean follow-up of 45.8 months, late stroke occurred in 1 case. Recanalization was observed in 2 cases, and contralateral VA stenosis in others.
  • Low incidence of late clinical (1.2%/patient-year) and radiological (1.1%/patient-year) events.

Conclusions:

  • Mid- to long-term outcomes after PAO are stable, with a lower-than-expected risk of late stroke or de novo aneurysm formation.
  • Further studies comparing PAO with reconstructive techniques are warranted.
Abstract

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