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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • In vitro experiments are crucial for evaluating medical devices and techniques.
  • Current anatomical models lack the variability of real-world vessel sizes, limiting experimental interpretation.
  • Understanding the distribution of cerebral vessel diameters is essential for accurate preclinical research.

Purpose of the Study:

  • To characterize the distribution of cerebral vessel diameters in a real-world population.
  • To provide data for developing more anatomically representative models for in vitro studies.
  • To improve the translation of medical device research from bench to bedside.

Main Methods:

  • Systematic literature review of PubMed database (2000-2022).
  • Analysis of cerebral vessel diameter measurements from 76 studies.
  • Random-effects meta-analyses and generation of predicted diameter distributions.

Main Results:

  • Sufficient data for diameter distributions were found for the M1 segment, internal carotid artery (cervical and communicating), A1 segment, V2 segment, V4 segment, and basilar artery.
  • Mean diameters ranged from 1.89 ± 0.34 mm (A1 segment) to 4.74 ± 0.64 mm (internal carotid artery-cervical segment).
  • Significant interpercentile ranges highlight substantial variability in vessel sizes across different cerebral arteries.

Conclusions:

  • Cerebral vessel diameter measurements exhibit considerable variation influenced by patient-specific factors and imaging methods.
  • This review underscores the necessity of anatomical models that reflect the diversity of vessel sizes observed clinically.
  • Accurate representation of cerebral vasculature is vital for advancing medical device development and understanding treatment efficacy.