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Anaesthesia-induced atelectasis in a rat model (Rattus norvegicus)
A Piskovská1,2, K Kraszewska3, M Gajewski3
1Jekl & Hauptman Veterinary Clinic, Brno, Czechia.
Frontiers in Veterinary Science
|January 26, 2026
Summary
Anesthesia can cause lung atelectasis in rats, detectable by lung ultrasound. A modified scoring system showed good agreement among observers for assessing these anesthesia-induced lung changes.
Area of Science:
- Veterinary Medicine
- Diagnostic Imaging
- Anesthesiology
Background:
- Anesthesia can induce lung atelectasis in various animal species.
- Lung ultrasonography is a rapid, non-invasive method for detecting atelectasis.
- Rats are a common model for preclinical research, making their physiological responses to anesthesia relevant.
Purpose of the Study:
- To describe anesthesia-induced atelectasis in rats using lung ultrasound.
- To evaluate the reliability of a modified lung ultrasound scoring system (LUSS) in a rat model.
- To assess interobserver agreement for the modified LUSS.
Main Methods:
- 12 Wistar rats underwent isoflurane anesthesia.
- Lung ultrasound was performed before, during, and after anesthesia induction.
- A modified Oricco's LUSS was adapted and applied by two independent scorers.
Main Results:
- No lung pathology was observed in conscious rats.
- The modified LUSS demonstrated high interobserver agreement during and after anesthesia induction.
- Histopathological examination revealed no abnormalities.
Conclusions:
- Anesthesia with isoflurane can cause detectable ultrasonographic changes in rat lungs.
- The modified LUSS is a reliable tool for thoracic ultrasound in rats.
- This scoring system has potential for use in laboratory and pet rats.
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