Overweight worsens the metabolic presentation of type 1 diabetes mellitus in children
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View abstract on PubMed
Summary
This summary is machine-generated.Overweight and obese children with type 1 diabetes mellitus (T1DM) present with more severe metabolic issues and a higher risk of diabetic ketoacidosis (DKA). Elevated C-peptide levels suggest preserved beta-cell function in these patients.
Area Of Science
- Pediatric Endocrinology
- Metabolic Disorders
- Immunology
Background
- Global rise in type 1 diabetes mellitus (T1DM) and obesity prevalence.
- Overweight and obesity impact T1DM pathogenesis and complications.
Purpose Of The Study
- Investigate the effect of excess body weight on T1DM clinical presentation.
- Analyze metabolic parameters at diagnosis in relation to BMI Z-scores.
Main Methods
- Retrospective, single-center cohort study of 994 children diagnosed with T1DM (2014-2023).
- Patients categorized into normal-weight, overweight, and obese groups based on BMI Z-scores.
- Comparison of metabolic parameters and anthropometric data between groups.
Main Results
- Combined 10-year prevalence of overweight/obesity was 15.9%.
- Significant differences observed in pH, bicarbonate, pCO2, and C-peptide levels between groups.
- Higher rates of diabetic ketoacidosis (DKA) and severe DKA in overweight and obese children.
Conclusions
- Overweight children exhibit more severe metabolic derangement at T1DM onset.
- Obese and overweight children have increased DKA risk despite higher C-peptide levels.
- Findings suggest other factors like inflammation may influence T1DM manifestation.
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