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Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Gene Flow02:39

Gene Flow

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Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Epistasis01:39

Epistasis

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In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Photoreceptors and Plant Responses to Light02:00

Photoreceptors and Plant Responses to Light

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Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
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Related Experiment Video

Updated: Jan 28, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
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Following the Dynamics of Structural Variants in Experimentally Evolved Populations

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Hypergranulotic Dyscornification - Alba Variant.

C K SriRam1, A S Krishnaram1, I Shibani1

  • 1From the Department of Dermatology, Venereology and Leprosy, Velammal Medical College, Madurai, Tamil Nadu, India.

Indian Journal of Dermatology
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

Hypergranulotic dyscornification (HGD) is a rare skin condition diagnosed histologically. This case highlights HGD presenting with unusual depigmentation, a finding not previously documented in medical literature.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Oncology

Background:

  • Hypergranulotic dyscornification (HGD) is a histopathologic reaction pattern characterized by abnormal corneocyte maturation.
Keywords:
Depigmented noduleshypergranulotic dyscornificationkeratohyaline granulesvitiligo

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  • HGD lacks specific clinical manifestations, making histological examination crucial for diagnosis.
  • The condition's rarity and varied presentations necessitate further case reporting.