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M1, M2: Time to Bid Adieu!

Sumit Roy1

  • 1Department of Radiology Stavanger University Hospital Stavanger Norway.

Stroke (Hoboken, N.J.)
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

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New classification for acute stroke occlusions in the middle cerebral artery

Area of Science:

  • Neuroendovascular treatment
  • Acute ischemic stroke
  • Cerebrovascular diseases

Background:

  • Limited data exists on occlusions in terminal middle cerebral artery divisions and lateral sulcus branches.
  • Current practice groups these as M2 segment lesions, hindering specific analysis.
  • This lack of granular data impedes progress in transcatheter thrombectomy.

Purpose of the Study:

  • To propose an alternative, clinically relevant anatomic characterization for middle cerebral artery terminal occlusions.
  • To facilitate more precise reporting of endovascular treatment outcomes.
  • To address the knowledge gap in treating these specific stroke locations.

Main Methods:

  • Review of existing literature and imaging data.
  • Development of a new classification system based on distinct anatomical landmarks.
Keywords:
acute strokecerebral angiographydiagnostic imagingendovascular procedurespercutaneous thrombectomy

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  • Proposal for its application in reporting endovascular stroke treatment results.
  • Main Results:

    • A novel classification system for middle cerebral artery terminal occlusions is presented.
    • This system utilizes readily available anatomical features for clinical relevance.
    • It offers a more detailed approach than the current M2 segment grouping.

    Conclusions:

    • The proposed anatomic classification can improve data granularity for stroke occlusions.
    • Adoption of this system could enhance understanding of transcatheter thrombectomy efficacy.
    • This approach aims to fill critical knowledge gaps in cerebrovascular research.