Related Experiment Video
Updated: Jan 28, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
Effects of repetitive transcranial magnetic stimulation on upper extremity motor function in stroke survivors: study
1Department of Rehabilitation, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background:
Stroke is a group of diseases with neurological deficits caused by cerebrovascular lesions. Despite standard treatment, a large number of patients are left with significant upper extremity motor dysfunction. Therefore, improving upper limb motor function and promoting neurological recovery in stroke patients has become a core challenge in the field of neurorehabilitation.
Methods And Analysis:
This study will be designed as a randomized, sham controlled clinical trial. Thirty-six patients with upper limb motor dysfunction after stroke will be included, and their Fugl-Meyer Upper Extremity Motor Function Rating Scale (FMA-UE) score will be ≤ 26 points. Subjects will be randomly assigned to the following three groups (n = 12/group): HF-rTMS: Treated with high-frequency (5 Hz) repetitive transcranial magnetic stimulation (rTMS) on the dorsal premotor cortex (PMd) on the contralesional side. Low-frequency group (LF-rTMS): Treated with low-frequency (1 Hz) rTMS on the primary motor cortex (M1) on the contralesional side. Sham control group: The stimulation target and parameter settings will be the same as those of the high-frequency group, but the coil will be placed perpendicular to the scalp plane. The intervention regimen will be rTMS treatment once daily, five times a week for 3 weeks. Outcome measures: Main outcome measures: Upper limb motor function, assessed by FMA-UE. Secondary outcomes: Barthel Index (BI), National Institutes of Health Stroke Scale (NIHSS). Exploratory indicators: fMRI data and motor evoked potential (MEP) parameters. All assessment data will be collected before and after the intervention.
Communication And Ethics:
This study has been reviewed and approved by the Basic and Clinical Research Ethics Committee of Sichuan Provincial People's Hospital (Lun Shen (Yan) No. 353-1 of 2025). The results of this research will be disseminated through the network of professionals and the general public, and peer-reviewed scientific papers will be published and presented at relevant conferences.
Registration:
This trial has been registered with the Chinese Clinical Trials Registry with registration number ChiCTR2500105502.
More Related Videos
Related Concept Videos
Hierarchy of Motor Control
Motor Unit Stimulation
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
Transfer Function in Control Systems
To derive the transfer function, consider a general nth-order linear time-invariant...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Clinical Trials: Overview

